Seroatlas · Human Serome Atlas

GGT5

Glutathione hydrolase 5 proenzyme

Also known as: GGT-REL, GGT5_HUMAN, GGTLA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P36269
Gene
GGT5
Ensembl
ENSG00000099998
Chromosome
22
Canonical length
586 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoli fibrillar center

OverviewNCBI Gene

This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

586 residues, UniProt reviewed canonical sequence.

>P36269|GGT5
     1  MARGYGATVS LVLLGLGLAL AVIVLAVVLS RHQAPCGPQA FAHAAVAADS KVCSDIGRAI
    61  LQQQGSPVDA TIAALVCTSV VNPQSMGLGG GVIFTIYNVT TGKVEVINAR ETVPASHAPS
   121  LLDQCAQALP LGTGAQWIGV PGELRGYAEA HRRHGRLPWA QLFQPTIALL RGGHVVAPVL
   181  SRFLHNSILR PSLQASTLRQ LFFNGTEPLR PQDPLPWPAL ATTLETVATE GVEVFYTGRL
   241  GQMLVEDIAK EGSQLTLQDL AKFQPEVVDA LEVPLGDYTL YSPPPPAGGA ILSFILNVLR
   301  GFNFSTESMA RPEGRVNVYH HLVETLKFAK GQRWRLGDPR SHPKLQNASR DLLGETLAQL
   361  IRQQIDGRGD HQLSHYSLAE AWGHGTGTSH VSVLGEDGSA VAATSTINTP FGAMVYSPRT
   421  GIILNNELLD LCERCPRGSG TTPSPVSGDR VGGAPGRCWP PVPGERSPSS MVPSILINKA
   481  QGSKLVIGGA GGELIISAVA QAIMSKLWLG FDLRAAIAAP ILHVNSKGCV EYEPNFSQEV
   541  QRGLQDRGQN QTQRPFFLNV VQAVSQEGAC VYAVSDLRKS GEAAGY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GGT5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.21
Highest tissue expression
124 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 124 nTPM
  • blood vessel: 101 nTPM
  • thyroid gland: 101 nTPM
  • heart muscle: 87 nTPM
  • breast: 83 nTPM
  • kidney: 75 nTPM

Single-cell type

  • hepatic stellate cells: 374 nCPM
  • pericytes: 242 nCPM
  • lymphatic endothelial cells: 114 nCPM
  • fibroblasts: 105 nCPM
  • decidual stromal cells: 63 nCPM
  • vascular endothelial cells: 51 nCPM

Immune cell

  • eosinophil: 4.5 nTPM
  • basophil: 2.3 nTPM
  • neutrophil: 1 nTPM
  • classical monocyte: 0.5 nTPM
  • NK-cell: 0.4 nTPM
  • intermediate monocyte: 0.2 nTPM

Brain region

  • medulla oblongata: 59 nTPM
  • midbrain: 49 nTPM
  • pons: 48 nTPM
  • thalamus: 45 nTPM
  • hypothalamus: 45 nTPM
  • spinal cord: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
0.69
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GGT5 as an antibody target. Whether an autoantibody or antibody against GGT5 could matter depends on whether native GGT5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GGT5 is annotated at the cell surface, where native GGT5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GGT5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GGT5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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