Seroatlas · Human Serome Atlas

GGT3P

Putative glutathione hydrolase 3 proenzyme

Also known as: GGT3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NGU5
Gene: GGT3P
Canonical length: 568 aa

OverviewNCBI Gene

No narrative summary is available for GGT3P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

568 residues, UniProt reviewed canonical sequence.

>A6NGU5|GGT3P
     1  MKKKLVVLGL LAVVLVLVIV GLCLWLPSAS KEPDNHVYTR AAVAADAKQC LEIGRDTLRD
    61  GGSAVDAAIA ALLCVGLMNA HSMGIGVGLF LTIYNSTTRK AEVINAREVA PRLAFASMFN
   121  SSEQSQKGGL SVAVPGEIRG YELAHQRHGR LPWARLFQPS IQLARQGFPV GKGLAAVLEN
   181  KRTVIEQQPV LCEVFCRDRK VLREGERLTL PRLADTYEML AIEGAQAFYN GSLMAQIVKD
   241  IQAAGGIVTA EDLNNYCAEL IEHPLNISLG DAVLYMPSAR LSGPVLALIL NILKGYNFSR
   301  ESVETPEQKG LTYHRIVEAF RFAYAKRTLL GDPKFVDVTE VVRNMTSEFF AAQLRSQISD
   361  HTTHPISYYK PEFYTPDDGG TAHLSVVAED GSAVSATSTI NLYFGSKVCS PVSGILFNNM
   421  DDFSSPSITN EFGAPPSPAN FIQPGKQPLL SMCPTIMVGQ DGQVRMVVGA AGGTQITTDT
   481  ALAIIYNLWF GYDVKRAVEE PRLHNKLLPN VTTVERNIDQ AVTAALETRH HHTQIASTFI
   541  AVVQAIVRTA GGWAAASDSR KGGEPAGY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GGT3P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.2

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GGT3P as an antibody target. Whether an autoantibody or antibody against GGT3P could matter depends on whether native GGT3P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GGT3P is annotated at the cell surface, where native GGT3P is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GGT3P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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