Seroatlas · Human Serome Atlas

GGH

Gamma-glutamyl hydrolase

Also known as: GATD10, GGH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92820
Gene
GGH
Ensembl
ENSG00000137563
Chromosome
8
Canonical length
318 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum,Vesicles
Secretome location
Intracellular and membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q92820|GGH
     1  MASPGCLLCV LGLLLCGAAS LELSRPHGDT AKKPIIGILM QKCRNKVMKN YGRYYIAASY
    61  VKYLESAGAR VVPVRLDLTE KDYEILFKSI NGILFPGGSV DLRRSDYAKV AKIFYNLSIQ
   121  SFDDGDYFPV WGTCLGFEEL SLLISGECLL TATDTVDVAM PLNFTGGQLH SRMFQNFPTE
   181  LLLSLAVEPL TANFHKWSLS VKNFTMNEKL KKFFNVLTTN TDGKIEFIST MEGYKYPVYG
   241  VQWHPEKAPY EWKNLDGISH APNAVKTAFY LAEFFVNEAR KNNHHFKSES EEEKALIYQF
   301  SPIYTGNISS FQQCYIFD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GGH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
177 nTPM

Expression across tissuesHPA

Tissue

  • liver: 177 nTPM
  • kidney: 117 nTPM
  • rectum: 70 nTPM
  • placenta: 52 nTPM
  • colon: 51 nTPM
  • bone marrow: 41 nTPM

Single-cell type

  • syncytiotrophoblasts: 882 nCPM
  • cytotrophoblasts: 652 nCPM
  • early spermatids: 532 nCPM
  • extravillous trophoblasts: 372 nCPM
  • oocytes: 336 nCPM
  • migrating cytotrophoblasts: 252 nCPM

Immune cell

  • plasmacytoid DC: 31 nTPM
  • memory B-cell: 6.5 nTPM
  • NK-cell: 4.5 nTPM
  • neutrophil: 3 nTPM
  • naive B-cell: 2.8 nTPM
  • T-reg: 2.7 nTPM

Brain region

  • thalamus: 14 nTPM
  • pons: 12 nTPM
  • choroid plexus: 11 nTPM
  • medulla oblongata: 9.3 nTPM
  • hypothalamus: 7.9 nTPM
  • cerebral cortex: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.58
gnomAD missense Z
0.45
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

  • tetrahydrofolylpolyglutamate metabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GGH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GGH as an antibody target. Whether an autoantibody or antibody against GGH could matter depends on whether native GGH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GGH is annotated as secreted, so native GGH circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GGH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GGH. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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