GARIN6
Golgi-associated RAB2 interactor protein 6
Also known as: FAM71C, GAR6_HUMAN, MGC39520
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NEG0
- Gene
- GARIN6
- Ensembl
- ENSG00000180219
- Chromosome
- 12
- Canonical length
- 241 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for GARIN6 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
241 residues, UniProt reviewed canonical sequence.
>Q8NEG0|GARIN6
1 MEDCCMLPYY TAQSSPAMGM FNTSMGKLQR QLYKGEYTIF RYAPMFESDF IQISKRGEVI
61 DVHNRARMVT MGIVRTSPCL TLPDVMLLAR PAAVCDNARC GPATQKRESP PAEILELTRL
121 LPLMFVKITI HNSVKKQLHL KLATGRSFYL QLCPPSDASE DLFVHWENLV YILRPPVEAY
181 SDTRAILAGN TLDSSVLEEV QRSPVGYAMK FCEEKEQFRI SRLHMNAEMF GSTYCDYTIE
241 ILocalizationUniProt · AlphaFold · HPA
Whether an antibody against GARIN6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 32 nTPM
Expression across tissuesHPA
Tissue
- testis: 32 nTPM
- cerebellum: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- late spermatids: 747 nCPM
- early spermatids: 419 nCPM
- late primary spermatocytes: 14 nCPM
- epicardial cells: 6.8 nCPM
- retinal ganglion cells: 3.9 nCPM
- medullary thymic epithelial cells: 2.4 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 16 nTPM
- cerebral cortex: 7.2 nTPM
- white matter: 4.5 nTPM
- basal ganglia: 4.2 nTPM
- hypothalamus: 2.7 nTPM
- hippocampal formation: 2.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.01
- gnomAD pLI
- 0.17
- DepMap mean gene effect
- 0.11
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GARIN6 as an antibody target. Whether an autoantibody or antibody against GARIN6 could matter depends on whether native GARIN6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GARIN6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GARIN6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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