Seroatlas · Human Serome Atlas

GARIN5B

Golgi-associated RAB2 interactor protein 5B

Also known as: C19orf16, DKFZp434G1729, FAM71E2, GAR5B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5Q1
Gene: GARIN5B
Ensembl: ENSG00000180043
Chromosome: 19
Canonical length: 922 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to act upstream of or within several processes, including flagellated sperm motility; penetration of zona pellucida; and spermatid development. Predicted to be active in sperm head. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

922 residues, UniProt reviewed canonical sequence.

>Q8N5Q1|GARIN5B
     1  MIWLRNRRCL EPLQGTPKWV PVLGELQKTL QKGEYLPLRP LPMFESNFVQ VTHQGGPVFV
    61  NHRTNRLAMG VAASLPGLVL PDILLIGQPA EDRDCSGLVL TRMIPLDLVH LCVHDLSAWR
   121  LKLRLVSGRQ YYLALDAPDN EVGFLFHCWV RLINLLQEPA PTWTPRTTRT APLDMPLAEA
   181  PASTWHLQDQ PISRHAVRVA ERNFPHKTVA AQRQRKAKAL KRSFKSQAVG DSVPLIWSQL
   241  EHADVRKKPA EKKSHSDPRP DRTHTQIRLP EKTSITTWTI FSIISSTANQ TQSSPKACTS
   301  ASDEATGQGH VVESPSHCVS ADSPDGFFLG SCSSLDPCLW HQDTEDLMDS GGSTLSSAAS
   361  GLAPYPPAAC LSTPYSSIPR GREKAGPMGS HQGPGPPPCQ KAPSGLVTSC KAPFLVDQSQ
   421  KLPAVPASSW KPPPGLAPPQ KAPAASAPPR KAPAVPAPSQ KAPAVPAPSQ KAPAIPAPSR
   481  KASAASASPR KASAVPAPPQ KTPPPSQKAP SVPTIPQKAV SPTAPKKKSL LLPAPSQKAL
   541  PTSPTEYQMA LSPPASRGKL PGDFDVLPTG IPGRAVLERS QSGGKPEPVV TVRTQETDVV
   601  EMTTQAKSPE SPFTVTKKES KDILISQTKE VTLEAFRGQG KLEDWAHWAK LEERSPDLPG
   661  VRSKELEQRK RWVKAKELAV EGPSQEHSRP FSVEALTLTK LMITANSKEQ PSKSALVSLP
   721  SWLLATPQAS ATSMMASVPS RPGQLSLLEG KPVVVREQPE SHTWVKEGKR PWGEMKEQPW
   781  GEMKEPPWDP KGPPKVPFRS KPTSASLKRE GISQAPIPLT ASPWEDLRPS PLSETLISKM
   841  EATARASQQP KRVSQEPMRM PAQHPLATVG SSSEILLPML LELETVRNTA TKAEEIQEES
   901  GVLNLLPSLQ HSQHSEWPDA GA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GARIN5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

testis: 26 nTPM
hypothalamus: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late spermatids: 16 nCPM
early spermatids: 5.2 nCPM
late primary spermatocytes: 1.9 nCPM
ependymal cells: 0.3 nCPM
undifferentiated spermatogonia: 0.2 nCPM
decidual stromal cells: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 0.3 nTPM
pons: 0.2 nTPM
cerebellum: 0.1 nTPM
medulla oblongata: 0.1 nTPM
thalamus: 0.1 nTPM
amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GARIN5B as an antibody target. Whether an autoantibody or antibody against GARIN5B could matter depends on whether native GARIN5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GARIN5B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GARIN5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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