Seroatlas · Human Serome Atlas

GARIN4

Golgi-associated RAB2 interactor protein 4

Also known as: FAM71A, FLJ32796, GAR4_HUMAN, GARI-L4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYT1
Gene: GARIN4
Ensembl: ENSG00000162771
Chromosome: 1
Canonical length: 594 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein that interacts with the Rab2B small GTPase and may be important for integrity of the Golgi body. A knockdown of this gene induces fragmentation of the Golgi, similar to the effect seen with a knockdown of the Rab2B small GTPase. The encoded protein has an N-terminal Rab-binding domain specific for Rab2B. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

594 residues, UniProt reviewed canonical sequence.

>Q8IYT1|GARIN4
     1  MNADFLLPYY TAQSGSSMSM FNTTMGKLQR QLYKGEYDIF KYAPIFESDF IQITKRGEVI
    61  DVHNRVRMVT MGIARTSPIL PLPDVMLLAR PATGCEEYAG HGQATKRKKR KAAKNLELTR
   121  LLPLRFVRIS VQDHEKQQLR LKFATGRSCY LQLCPALDTR DDLFAYWEKL IYLLRPPMES
   181  NSSTCGIPAE DMMWMPVFQE DRRSLGAVNL QGKGDQDQVS IQSLHMVSEV CGATSAAYAG
   241  GEGLQNDFNK PTNVLNASIP KTSTELAEEP ATGGIKEAAA AGAAAGAATG TVAGALSVAA
   301  ANSAPGQVSA AIAGAATIGA GGNKGNMALA GTASMAPNST KVAVAGAAGK SSEHVSSASM
   361  SLSREGSVSL AIAGVVLTSR TAAEADMDAA AGPPVSTRQS KSSLSGQHGR ERTQASAEGC
   421  KEGRERREKD RALGRSSHRR RTGESRHKTR GDKIAQKSSS RSSFSHRANR DDKKEKGCGN
   481  PGSSRHRDSH KGVSHTPISK ESRTSHKSGR SLWTTSSGSS KGLGRVSSFL RNVRANLTTK
   541  VVGTPHGRDV NVMAKMAERS TNVAIAETAE GGQGLETVGS MTPDIMETVT FEAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GARIN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

testis: 75 nTPM
skin: 0.7 nTPM
bone marrow: 0.4 nTPM
fallopian tube: 0.4 nTPM
adipose tissue: 0.3 nTPM
smooth muscle: 0.3 nTPM

Single-cell type

early spermatids: 1,547 nCPM
late spermatids: 602 nCPM
late primary spermatocytes: 40 nCPM
endometrial luminal cells: 30 nCPM
salivary acinar cells: 14 nCPM
respiratory deuterosomal cells: 10 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 1 nTPM
cerebral cortex: 0.2 nTPM
medulla oblongata: 0.2 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM
midbrain: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0
gnomAD pLI: 0
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Golgi apparatus

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GARIN4 as an antibody target. Whether an autoantibody or antibody against GARIN4 could matter depends on whether native GARIN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GARIN4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GARIN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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