Seroatlas · Human Serome Atlas

GARIN3

Golgi-associated RAB2 interactor protein 3

Also known as: FAM71B, GAR3_HUMAN, GARI-L3, MGC26988

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TC56
Gene: GARIN3
Ensembl: ENSG00000170613
Chromosome: 5
Canonical length: 605 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in gene expression and vacuole organization. Predicted to act upstream of or within several processes, including acrosome assembly; binding activity of sperm to zona pellucida; and penetration of zona pellucida. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

605 residues, UniProt reviewed canonical sequence.

>Q8TC56|GARIN3
     1  MSNESCLPYY TAHSYSSMSA FKTSMGDLQR QLYNRGEYNI FKYAPMFESN FIQINKKGEV
    61  IDVHNRVRMV TVGIVCTSPI LPLPDVMVLA QPTKICEQHV RWGRFAKGRG RRPVKTLELT
   121  RLLPLKFVKI SIHDHEKQQL RLKLATGRTF YLQLCPSSDT REDLFCYWEK LVYLLRPPVE
   181  SYCSTPTLLS GDAPPEDNKS LVAAELHREG DQSETGLYKP CDVSAATSSA YAGGEGIQHA
   241  SHGTASAASP STSTPGAAEG GAARTAGGMA VAGTATGPRT DVAIAGAAMS PATGAMSIAT
   301  TKSAGPGQVT TALAGAAIKN PGENESSKSM AGAANISSEG ISLALVGAAS TSLEGTSTSM
   361  AGAASLSQDS SLSAAFAGSI TTSKCAAERT EGPAVGPLIS TLQSEGYMSE RDGSQKVSQP
   421  SAEVWNENKE RREKKDRHPS RKSSHHRKAG ESHRRRAGDK NQKASSHRSA SGHKNTRDDK
   481  KEKGYSNVRG KRHGSSRKSS THSSTKKESR TTQELGKNQS ASSTGALQKK ASKISSFLRS
   541  LRATPGSKTR VTSHDREVDI VAKMVEKQNI EAKVEKAQGG QELEMISGTM TSEKTEMIVF
   601  ETKSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GARIN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

testis: 30 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 1,137 nCPM
late spermatids: 525 nCPM
late primary spermatocytes: 25 nCPM
sertoli cells: 2.8 nCPM
leydig cells: 2.1 nCPM
undifferentiated spermatogonia: 0.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GARIN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FRG1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GARIN3 as an antibody target. Whether an autoantibody or antibody against GARIN3 could matter depends on whether native GARIN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GARIN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GARIN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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