Seroatlas · Human Serome Atlas

GARIN1B

Golgi-associated RAB2 interactor protein 1B

Also known as: FAM137A, FAM71F1, GAR1B_HUMAN, GARI-L1, NYD-SP18

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KD3
Gene: GARIN1B
Ensembl: ENSG00000135248
Chromosome: 7
Canonical length: 344 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to be involved in acrosome assembly and acrosome reaction. Predicted to be located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q96KD3|GARIN1B
     1  MLSSFPHRKT WRKSKKTVKV TRSYPTFPSL NAWEEFRGLL PVDGEPNPGA GLGVEEGLLC
    61  RVVHSPEFNL FLDSVVFESN FIQVKRGRNW RDVYKASNTM ALGVTSSVPC LPLPNILLMA
   121  SVKWHQGQNQ TWNRPSIAPN IFLKRILPLR FVELQVCDHY QRILQLRTVT EKIYYLKLHP
   181  DHPETVFHFW IRLVQILQKG LSITTKDPRI LVTHCLVPKN CSSPSGDSKL VQKKLQASQP
   241  SESLIQLMTK GESEALSQIF ADLHQQNQLS FRSSRKVETN KNSSGKDSSR EDSIPCTCDL
   301  RWRASFTYGE WERENPSGLQ PLSLLSTLAA STGPQLAPPI GNSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GARIN1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 89 nTPM

Expression across tissuesHPA

Tissue

testis: 89 nTPM
midbrain: 0.9 nTPM
retina: 0.9 nTPM
basal ganglia: 0.8 nTPM
amygdala: 0.7 nTPM
cerebral cortex: 0.5 nTPM

Single-cell type

late spermatids: 3,032 nCPM
early spermatids: 1,409 nCPM
late primary spermatocytes: 332 nCPM
cone photoreceptor cells: 10 nCPM
epididymal clear cells: 10 nCPM
sertoli cells: 10 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 1.8 nTPM
thalamus: 1.6 nTPM
amygdala: 1.3 nTPM
pons: 1.2 nTPM
cerebral cortex: 1.1 nTPM
basal ganglia: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Golgi apparatus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Golgi apparatus

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GARIN1B as an antibody target. Whether an autoantibody or antibody against GARIN1B could matter depends on whether native GARIN1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GARIN1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GARIN1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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