Seroatlas · Human Serome Atlas

GARIN1A

Golgi-associated RAB2 interactor protein 1A

Also known as: FAM137B, FAM71F2, GAR1A_HUMAN, GARI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NXP2
Gene: GARIN1A
Ensembl: ENSG00000205085
Chromosome: 7
Canonical length: 309 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in acrosome assembly. Predicted to be located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q6NXP2|GARIN1A
     1  MSKIRGLPPE VREPGPGVEL GVENGLLCQL IHSPEFNLFS NSVVFESNFI QTHVPEADFQ
    61  VTKPGNWRDV CEGSATVILG VTSSVPSLPL PNVLLMANVT WPQGPFTTWS TPGDAPVINL
   121  SRLLPLKYVE LRIYDRLQRI LRVRTVTEKI YYLKLHEKHP EIVFQFWVRL VKILQKGLSI
   181  TTKDPRIKFT HCLVPKMPTN STETTPENSL LSSPQPSEPL VLLAAEQTSG SFSQLSGKPQ
   241  LTADRNNDTA IEIDNCSSYK IPSPVASPIN LNIPMRAALS HSLWEQEDWN EHLLQVHIAS
   301  YLGEHFLGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GARIN1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 5.7 nTPM

Expression across tissuesHPA

Tissue

testis: 5.7 nTPM
retina: 1.7 nTPM
skeletal muscle: 1 nTPM
bone marrow: 0.9 nTPM
choroid plexus: 0.8 nTPM
skin: 0.7 nTPM

Single-cell type

late spermatids: 1,098 nCPM
early spermatids: 177 nCPM
neutrophils: 25 nCPM
cone photoreceptor cells: 19 nCPM
late primary spermatocytes: 18 nCPM
myonuclei: 18 nCPM

Immune cell

basophil: 1.6 nTPM
neutrophil: 1.1 nTPM
NK-cell: 0.4 nTPM
plasmacytoid DC: 0.4 nTPM
naive B-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM

Brain region

white matter: 12 nTPM
cerebral cortex: 10 nTPM
amygdala: 10 nTPM
cerebellum: 10 nTPM
thalamus: 10 nTPM
medulla oblongata: 9.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0.02
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

acrosome assembly

Cellular components

Golgi apparatus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GARIN1A as an antibody target. Whether an autoantibody or antibody against GARIN1A could matter depends on whether native GARIN1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GARIN1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GARIN1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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