Seroatlas · Human Serome Atlas

GABRR3

Gamma-aminobutyric acid receptor subunit rho-3

Also known as: GBRR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MPY1
Gene: GABRR3
Ensembl: ENSG00000183185
Chromosome: 3
Canonical length: 467 aa
Protein class: Predicted membrane proteins
Quaternary structure: Homopentamer

OverviewNCBI Gene

The neurotransmitter gamma-aminobutyric acid (GABA) functions in the central nervous system to regulate synaptic transmission of neurons. This gene encodes one of three related subunits, which combine as homo- or hetero-pentamers to form GABA(C) receptors. In humans, some individuals contain a single-base polymorphism (dbSNP rs832032) that is predicted to inactivate the gene product. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

467 residues, UniProt reviewed canonical sequence.

>A8MPY1|GABRR3
     1  MVLAFQLVSF TYIWIILKPN VCAASNIKMT HQRCSSSMKQ TCKQETRMKK DDSTKARPQK
    61  YEQLLHIEDN DFAMRPGFGG SPVPVGIDVH VESIDSISET NMDFTMTFYL RHYWKDERLS
   121  FPSTANKSMT FDHRLTRKIW VPDIFFVHSK RSFIHDTTME NIMLRVHPDG NVLLSLRITV
   181  SAMCFMDFSR FPLDTQNCSL ELESYAYNED DLMLYWKHGN KSLNTEEHMS LSQFFIEDFS
   241  ASSGLAFYSS TGWYNRLFIN FVLRRHVFFF VLQTYFPAIL MVMLSWVSFW IDRRAVPARV
   301  SLGITTVLTM STIITAVSAS MPQVSYLKAV DVYLWVSSLF VFLSVIEYAA VNYLTTVEER
   361  KQFKKTGKIS RMYNIDAVQA MAFDGCYHDS EIDMDQTSLS LNSEDFMRRK SICSPSTDSS
   421  RIKRRKSLGG HVGRIILENN HVIDTYSRIL FPIVYILFNL FYWGVYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GABRR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

retina: 8.1 nTPM
testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

retinal bipolar cells: 119 nCPM
rod photoreceptor cells: 41 nCPM
thymocytes: 3.4 nCPM
cone photoreceptor cells: 2.1 nCPM
retinal horizontal cells: 2 nCPM
late primary spermatocytes: 1.6 nCPM

Immune cell

basophil: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 0.6 nTPM
cerebral cortex: 0.5 nTPM
pons: 0.5 nTPM
hippocampal formation: 0.4 nTPM
white matter: 0.4 nTPM
amygdala: 0.3 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GABRR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SQSTM1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GABRR3 as an antibody target. Whether an autoantibody or antibody against GABRR3 could matter depends on whether native GABRR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GABRR3 is annotated at the cell surface, where native GABRR3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GABRR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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