Seroatlas · Human Serome Atlas

GABRR2

Gamma-aminobutyric acid receptor subunit rho-2

Also known as: GBRR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P28476
Gene
GABRR2
Ensembl
ENSG00000111886
Chromosome
6
Canonical length
465 aa
Protein class
Predicted membrane proteins
Quaternary structure
Homopentamer

OverviewNCBI Gene

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA type A receptor complex. This gene exists on chromosome 6q next to the gene encoding the rho 1 subunit of the GABA type A receptor, in a region thought to be associated with susceptibility for psychiatric disorders and epilepsy. Polymorphisms in this gene may also be associated with alcohol dependence, and general cognitive ability. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>P28476|GABRR2
     1  MPYFTRLILF LFCLMVLVES RKPKRKRWTG QVEMPKPSHL YKKNLDVTKI RKGKPQQLLR
    61  VDEHDFSMRP AFGGPAIPVG VDVQVESLDS ISEVDMDFTM TLYLRHYWKD ERLAFSSASN
   121  KSMTFDGRLV KKIWVPDVFF VHSKRSFTHD TTTDNIMLRV FPDGHVLYSM RITVTAMCNM
   181  DFSHFPLDSQ TCSLELESYA YTDEDLMLYW KNGDESLKTD EKISLSQFLI QKFHTTSRLA
   241  FYSSTGWYNR LYINFTLRRH IFFFLLQTYF PATLMVMLSW VSFWIDRRAV PARVSLGITT
   301  VLTMTTIITG VNASMPRVSY VKAVDIYLWV SFVFVFLSVL EYAAVNYLTT VQERKERKLR
   361  EKFPCMCGML HSKTMMLDGS YSESEANSLA GYPRSHILTE EERQDKIVVH LGLSGEANAA
   421  RKKGLLKGQT GFRIFQNTHA IDKYSRLIFP ASYIFFNLIY WSVFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GABRR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • retina: 29 nTPM
  • spleen: 3.3 nTPM
  • kidney: 1.6 nTPM
  • lung: 1.6 nTPM
  • small intestine: 1.4 nTPM
  • heart muscle: 1.3 nTPM

Single-cell type

  • retinal bipolar cells: 799 nCPM
  • neutrophils: 61 nCPM
  • plasma cells: 18 nCPM
  • pdcs: 14 nCPM
  • retinal horizontal cells: 14 nCPM
  • retinal amacrine cells: 9 nCPM

Immune cell

  • neutrophil: 0.3 nTPM
  • basophil: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM

Brain region

  • cerebellum: 2.1 nTPM
  • white matter: 2.1 nTPM
  • cerebral cortex: 2 nTPM
  • thalamus: 1.9 nTPM
  • midbrain: 1.8 nTPM
  • medulla oblongata: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
0.3
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GABRR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GABRR2 as an antibody target. Whether an autoantibody or antibody against GABRR2 could matter depends on whether native GABRR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GABRR2 is annotated at the cell surface, where native GABRR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GABRR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GABRR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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