Seroatlas · Human Serome Atlas

GABRQ

Gamma-aminobutyric acid receptor subunit theta

Also known as: GBRT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UN88
Gene
GABRQ
Ensembl
ENSG00000268089
Chromosome
X
Canonical length
632 aa
Protein class
FDA approved drug targets, Predicted membrane proteins

OverviewNCBI Gene

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

632 residues, UniProt reviewed canonical sequence.

>Q9UN88|GABRQ
     1  MGIRGMLRAA VILLLIRTWL AEGNYPSPIP KFHFEFSSAV PEVVLNLFNC KNCANEAVVQ
    61  KILDRVLSRY DVRLRPNFGG APVPVRISIY VTSIEQISEM NMDYTITMFF HQTWKDSRLA
   121  YYETTLNLTL DYRMHEKLWV PDCYFLNSKD AFVHDVTVEN RVFQLHPDGT VRYGIRLTTT
   181  AACSLDLHKF PMDKQACNLV VESYGYTVED IILFWDDNGN AIHMTEELHI PQFTFLGRTI
   241  TSKEVYFYTG SYIRLILKFQ VQREVNSYLV QVYWPTVLTT ITSWISFWMN YDSSAARVTI
   301  GLTSMLILTT IDSHLRDKLP NISCIKAIDI YILVCLFFVF LSLLEYVYIN YLFYSRGPRR
   361  QPRRHRRPRR VIARYRYQQV VVGNVQDGLI NVEDGVSSLP ITPAQAPLAS PESLGSLTST
   421  SEQAQLATSE SLSPLTSLSG QAPLATGESL SDLPSTSEQA RHSYGVRFNG FQADDSIIPT
   481  EIRNRVEAHG HGVTHDHEDS NESLSSDERH GHGPSGKPML HHGEKGVQEA GWDLDDNNDK
   541  SDCLAIKEQF KCDTNSTWGL NDDELMAHGQ EKDSSSESED SCPPSPGCSF TEGFSFDLFN
   601  PDYVPKVDKW SRFLFPLAFG LFNIVYWVYH MY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GABRQ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 21 nTPM
  • cervix: 7.2 nTPM
  • hippocampal formation: 6.6 nTPM
  • cerebral cortex: 3.5 nTPM
  • amygdala: 3.4 nTPM
  • basal ganglia: 2.6 nTPM

Single-cell type

  • other brain neurons: 24 nCPM
  • adrenal medulla cells: 11 nCPM
  • retinal amacrine cells: 10 nCPM
  • brain excitatory neurons: 7.9 nCPM
  • brain inhibitory neurons: 6.2 nCPM
  • basal keratinocytes: 5.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 154 nTPM
  • cerebral cortex: 61 nTPM
  • midbrain: 59 nTPM
  • basal ganglia: 52 nTPM
  • pons: 48 nTPM
  • hippocampal formation: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
gnomAD missense Z
0.58
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GABRQ as an antibody target. Whether an autoantibody or antibody against GABRQ could matter depends on whether native GABRQ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GABRQ is annotated at the cell surface, where native GABRQ is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GABRQ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GABRQ. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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