Seroatlas · Human Serome Atlas

GABRP

Gamma-aminobutyric acid receptor subunit pi

Also known as: GBRP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00591
Gene
GABRP
Ensembl
ENSG00000094755
Chromosome
5
Canonical length
440 aa
Protein class
FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

440 residues, UniProt reviewed canonical sequence.

>O00591|GABRP
     1  MNYSLHLAFV CLSLFTERMC IQGSQFNVEV GRSDKLSLPG FENLTAGYNK FLRPNFGGEP
    61  VQIALTLDIA SISSISESNM DYTATIYLRQ RWMDQRLVFE GNKSFTLDAR LVEFLWVPDT
   121  YIVESKKSFL HEVTVGNRLI RLFSNGTVLY ALRITTTVAC NMDLSKYPMD TQTCKLQLES
   181  WGYDGNDVEF TWLRGNDSVR GLEHLRLAQY TIERYFTLVT RSQQETGNYT RLVLQFELRR
   241  NVLYFILETY VPSTFLVVLS WVSFWISLDS VPARTCIGVT TVLSMTTLMI GSRTSLPNTN
   301  CFIKAIDVYL GICFSFVFGA LLEYAVAHYS SLQQMAAKDR GTTKEVEEVS ITNIINSSIS
   361  SFKRKISFAS IEISSDNVDY SDLTMKTSDK FKFVFREKMG RIVDYFTIQN PSNVDHYSKL
   421  LFPLIFMLAN VFYWAYYMYF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GABRP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
161 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 161 nTPM
  • breast: 142 nTPM
  • endometrium: 46 nTPM
  • tonsil: 40 nTPM
  • retina: 39 nTPM
  • salivary gland: 34 nTPM

Single-cell type

  • endometrial luminal cells: 634 nCPM
  • endometrial glandular cells: 559 nCPM
  • esophageal apical cells: 399 nCPM
  • breast secretory cells: 361 nCPM
  • salivary duct cells: 317 nCPM
  • submucosal glandular cells: 184 nCPM

Immune cell

  • basophil: 12 nTPM
  • eosinophil: 6.2 nTPM
  • non-classical monocyte: 5.8 nTPM
  • neutrophil: 4.6 nTPM
  • total PBMC: 2.4 nTPM
  • classical monocyte: 2 nTPM

Brain region

  • hypothalamus: 142 nTPM
  • cerebral cortex: 132 nTPM
  • white matter: 129 nTPM
  • cerebellum: 125 nTPM
  • medulla oblongata: 121 nTPM
  • thalamus: 117 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0
gnomAD missense Z
0.16
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GABRP as an antibody target. Whether an autoantibody or antibody against GABRP could matter depends on whether native GABRP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GABRP is annotated at the cell surface, where native GABRP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GABRP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GABRP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...