Seroatlas · Human Serome Atlas

GABRG1

Gamma-aminobutyric acid receptor subunit gamma-1

Also known as: GBRG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N1C3
Gene
GABRG1
Ensembl
ENSG00000163285
Chromosome
4
Canonical length
465 aa
Protein class
FDA approved drug targets, Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>Q8N1C3|GABRG1
     1  MGPLKAFLFS PFLLRSQSRG VRLVFLLLTL HLGNCVDKAD DEDDEDLTVN KTWVLAPKIH
    61  EGDITQILNS LLQGYDNKLR PDIGVRPTVI ETDVYVNSIG PVDPINMEYT IDIIFAQTWF
   121  DSRLKFNSTM KVLMLNSNMV GKIWIPDTFF RNSRKSDAHW ITTPNRLLRI WNDGRVLYTL
   181  RLTINAECYL QLHNFPMDEH SCPLEFSSYG YPKNEIEYKW KKPSVEVADP KYWRLYQFAF
   241  VGLRNSTEIT HTISGDYVIM TIFFDLSRRM GYFTIQTYIP CILTVVLSWV SFWINKDAVP
   301  ARTSLGITTV LTMTTLSTIA RKSLPKVSYV TAMDLFVSVC FIFVFAALME YGTLHYFTSN
   361  QKGKTATKDR KLKNKASMTP GLHPGSTLIP MNNISVPQED DYGYQCLEGK DCASFFCCFE
   421  DCRTGSWREG RIHIRIAKID SYSRIFFPTA FALFNLVYWV GYLYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GABRG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 21 nTPM
  • amygdala: 18 nTPM
  • cerebral cortex: 17 nTPM
  • hypothalamus: 16 nTPM
  • midbrain: 12 nTPM
  • hippocampal formation: 11 nTPM

Single-cell type

  • ependymal cells: 383 nCPM
  • bergmann glia: 276 nCPM
  • astrocytes: 158 nCPM
  • retinal amacrine cells: 88 nCPM
  • other brain neurons: 78 nCPM
  • epididymal efferent duct ciliated cells: 38 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 79 nTPM
  • midbrain: 68 nTPM
  • medulla oblongata: 38 nTPM
  • thalamus: 37 nTPM
  • white matter: 32 nTPM
  • amygdala: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0
gnomAD missense Z
0.52
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GABRG1 as an antibody target. Whether an autoantibody or antibody against GABRG1 could matter depends on whether native GABRG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GABRG1 is annotated at the cell surface, where native GABRG1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GABRG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GABRG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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