Seroatlas · Human Serome Atlas

FREM3

FRAS1-related extracellular matrix protein 3

Also known as: FREM3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C091
Gene: FREM3
Ensembl: ENSG00000183090
Chromosome: 4
Canonical length: 2139 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The protein belongs to the family of FRAS1/FREM extracellular matrix proteins and may play a role cell adhesion. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

2139 residues, UniProt reviewed canonical sequence.

>P0C091|FREM3
     1  MAGASRHPTG TPRQLLVALA CLLLSRPALQ GRASSLGTEP DPALYLPARG ALDGTRPDGP
    61  SVLIANPGLR VPLGRSLWLD PLRDLVIGVQ PGDRCEVTVL DALPRLKGAL SPRRFPCTFG
   121  PRQVQYTHFG SHSPGRARVL LQLRYDAPTH TLVLPFTLAV DLVFSQLELV TRNRPLVVEK
   181  LRSWSRAIDR RVLDFASLKS GATATRRCRL TPLPHEDGPL PKYGRLVDAV GAPLPRGKGV
   241  DCEAFLRAGV RYQHTATSSP NRDYVPMMVE LLGPEGQDAG SAGVLVREHF QLLVRIRGGA
   301  ENTPPRPSFM ATMMMEVDPL VLTALTPDAL AAEDVESDPG DLVFNILNAP THPPGHPGQQ
   361  GYVVSTDDPL GLPVSFFTQQ ELRELKIAYQ PPAENSHGER LFQLELEVVD GDGAASDPFA
   421  FMVTVKSMNT LVPVASHNRG LVLFEGQSRP LSSTHSIPIS DKDNLEEVKM AAVRGLRHGQ
   481  LVVFGAPAGC KYFTPADLAA GRVVYQHDGS NTYSDNIIFR MEDGHHQVDF LFPLTILPVD
   541  DEPPMVNTNT GLSLTEGQVV QISPFVLSAT DIDSEDSTIH FVLENQPLKG NEEEPQWELA
   601  PGSSHSGHYL GDLLLQQAEL PLSTEDEDWH YMEKEGLYEK VVTEWLQRDI MEGRLFYRHL
   661  GPHSPQSVMV QLAFHVQDDH DPPNLSKQHI FTIKVQPVDI LSPQLYPGTT LEMTVQEYQL
   721  THFQKNFLRY IDQDSDDQNL WYTLLTLPTD TDGNHQVRAG EIVLTDSPDT LIMHFTQAQV
   781  NQHKVAYQPP QKLGIAPRVV QFTYQVEDAA GNSVPGTFTL FLQPVDNQPP EVTNRGFAIL
   841  EGGSFNLSSN ELHVTDPDTD IDQIVFILVR GPQHGHLQYF KRCMVPGESF MQADVINGSV
   901  SYQHGRDQTT TSDTFHLEVS DGVHHIPITI PISVHPNVAN RSPRISLRSS SLLDVSIDVL
   961  ENKATEITMG VIHGKRKDVG DLMLSFIVKD SPKLGTILVN GLPTERFTQE DLINGRVAYA
  1021  HTAGEVGFQK QHDAFSLILS KDSYQWVVGN SIIEKVQVQV TVLPVDNVGP KVFVGESFIV
  1081  YEGEKNSLTL QHLHVEDVDT HQDELLCTVT SQPASGYLEK IASAPGSKMS QSGSPISAFS
  1141  LRDIQVRHIN YVQSIHKGVE PQEDQFTFYC SDGINFSPNV FFPIIILPTN DEQPKLFAHE
  1201  FKVLEGMSLV IDTQLLNGAD ADLPPNELHF QLTALPRHGR IIQQLATGSQ PIHSFTLKEI
  1261  QEASTIVYEH DDSETKEDSF EVWLSDGKHT THRKVPIVVT LVDDETPHLT VNNGLKVEKG
  1321  HSEIITNRIL KATDLDSDDK SLSFVLHSGP QQGLLQRLRK PRGEVRNNLT LGMNFTQDEI
  1381  NRGLICYIHT GQEGIVDIIK FDVTDGVNTL TDHYFYVTIG NLDSVFPEVI SKRITLIEGA
  1441  RVTLTNNLLT NSDINSSDEH HFSITRAPSL GHLESSDYAG EPIASFTQLQ LASNKISYVH
  1501  TSNDEKKMDS FEFQVIGELY PVFRTFRIFI TDVDNKKPIL TIHRLTLQKE DSQLITLLEL
  1561  TVEDSDTPDD LILFTITQVP MHGKILYNGS RPVTTFTKQD LNKNLISYKH DGSETTEDSF
  1621  SLTVTDGTHT DFYVLPDTAL ATHKPQVMRV QIRSLDNRLP QITTNRGAPA LKRLHTGHMG
  1681  FLITSKSLKA EDQDSPHRLL KYKVTRGPEH GFIIKTGLGN QSTRVFTQAD IDEMKISYVL
  1741  NEGSNASKDI FYFSVEDNGG NKLTNQPFHL NWAWICLEKE YYIVDEDSTF LEVTLTRRGY
  1801  LGETSFISIG TKDETAKKDK DFKWKTNKQI QFNPGQTTAT WRVRIIPDNE YETSETFQII
  1861  LSEPLMAVLE FPEMATVEIV DPGDESTVYI PEAEYKIEED IGELLIPVRR SGDASQELIV
  1921  ICSTRQGSAT GTISSTVLFS DYISRPEDHT SILHFDKNET QKTCQVLIID DSLYEEEESF
  1981  SVSLRLPVGG QLGARFPTTK VTILADRYDE PVLHFGDAEY HVNESARYVE VCVWRRGTDL
  2041  SQPSSIAVRS RKSEQESAEA GTDYVGISRN LDFAPGVRMQ TFQVTILDDL GQPTLEGPEK
  2101  FELLLQMPMG AVLGEPNKTT IFIEDTITDC KQSACSSFD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FREM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 1.2 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 1.2 nTPM
thymus: 0.4 nTPM
lung: 0.3 nTPM
amygdala: 0.2 nTPM
hypothalamus: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

cardiomyocytes: 85 nCPM
epicardial cells: 36 nCPM
adipocytes: 23 nCPM
myonuclei: 18 nCPM
hepatic stellate cells: 13 nCPM
medullary thymic epithelial cells: 9.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 6 nTPM
basal ganglia: 4.8 nTPM
pons: 3.1 nTPM
thalamus: 2.9 nTPM
amygdala: 2.4 nTPM
hippocampal formation: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0
gnomAD missense Z: 2.97
DepMap mean gene effect: -0.1
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

metal ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FREM3 as an antibody target. Whether an autoantibody or antibody against FREM3 could matter depends on whether native FREM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FREM3 is annotated as secreted, so native FREM3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FREM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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