FRAS1-related extracellular matrix
IPR051561
Definition
The FRAS1 family proteins are extracellular matrix proteins that play crucial roles in tissue integrity, cell adhesion, and embryonic development. They are involved in the maintenance of the skin and renal epithelia, epidermal differentiation, and adhesion. These proteins are essential for the proper development of eyelids, anterior segment of the eyeballs, and brain organization. They also contribute to the regulation of epidermal-basement membrane adhesion, which is vital for organogenesis. The Calx-beta domains within these proteins bind calcium with high affinity, which induces a significant conformational change, suggesting a role in calcium-mediated signaling or structural stability. Some family members are implicated in cell proliferation, migration, and microvascular morphogenesis, potentially affecting processes like neurite outgrowth, collagen degradation, and plasminogen activation.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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