Seroatlas · Human Serome Atlas

FLYWCH1

FLYWCH-type zinc finger-containing protein 1

Also known as: DKFZp761A132, FWCH1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4VC44
Gene: FLYWCH1
Ensembl: ENSG00000059122
Chromosome: 16
Canonical length: 716 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Enables transcription coactivator binding activity and transcription corepressor activity. Involved in DNA damage response and negative regulation of transcription by RNA polymerase II. Located in cytosol; nuclear body; and pericentric heterochromatin. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

716 residues, UniProt reviewed canonical sequence.

>Q4VC44|FLYWCH1
     1  MPLPEPSEQE GESVKAGQEP SPKPGTDVIP AAPRKPREFS KLVLLTASDQ DEDGVGSKPQ
    61  EVHCVLSLEM AGPATLASTL QILPVEEQGG VVQPALEMPE QKCSKLDAAA PQSLEFLRTP
   121  FGGRLLVLES FLYKQEKAVG DKVYWKCRQH AELGCRGRAI TRGLRATVMR GHCHAPDEQG
   181  LEARRQREKL PSLALPEGLG EPQGPEGPGG RVEEPLEGVG PWQCPEEPEP TPGLVLSKPA
   241  LEEEEAPRAL SLLSLPPKKR SILGLGQARP LEFLRTCYGG SFLVHESFLY KREKAVGDKV
   301  YWTCRDHALH GCRSRAITQG QRVTVMRGHC HQPDMEGLEA RRQQEKAVET LQAGQDGPGS
   361  QVDTLLRGVD SLLYRRGPGP LTLTRPRPRK RAKVEDQELP TQPEAPDEHQ DMDADPGGPE
   421  FLKTPLGGSF LVYESFLYRR EKAAGEKVYW TCRDQARMGC RSRAITQGRR VTVMRGHCHP
   481  PDLGGLEALR QREKRPNTAQ RGSPGGPEFL KTPLGGSFLV YESFLYRREK AAGEKVYWTC
   541  RDQARMGCRS RAITQGRRVM VMRRHCHPPD LGGLEALRQR EHFPNLAQWD SPDPLRPLEF
   601  LRTSLGGRFL VHESFLYRKE KAAGEKVYWM CRDQARLGCR SRAITQGHRI MVMRSHCHQP
   661  DLAGLEALRQ RERLPTTAQQ EDPEKIQVQL CFKTCSPESQ QIYGDIKDVR LDGESQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FLYWCH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 31 nTPM
cerebellum: 31 nTPM
cerebral cortex: 28 nTPM
blood vessel: 23 nTPM
urinary bladder: 22 nTPM
basal ganglia: 20 nTPM

Single-cell type

rod photoreceptor cells: 94 nCPM
retinal ganglion cells: 81 nCPM
retinal pigment epithelial cells: 73 nCPM
myonuclei: 72 nCPM
retinal bipolar cells: 69 nCPM
cone photoreceptor cells: 68 nCPM

Immune cell

memory CD8 T-cell: 2.7 nTPM
naive B-cell: 2.7 nTPM
MAIT T-cell: 2.3 nTPM
memory CD4 T-cell: 2.1 nTPM
naive CD4 T-cell: 1.7 nTPM
naive CD8 T-cell: 1.6 nTPM

Brain region

medulla oblongata: 87 nTPM
pons: 80 nTPM
cerebral cortex: 76 nTPM
thalamus: 74 nTPM
midbrain: 67 nTPM
amygdala: 64 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: -2.61
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

FLYWCH-type zinc finger-containing protein, N-terminal
FLYWCH-type zinc finger-containing protein 1/2
FLYWCH-type zinc finger-containing protein
Zinc finger, FLYWCH-type
FLYWCH zinc finger domain
FLYWCH-type zinc finger-containing protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FLYWCH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CTNNB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FLYWCH1 as an antibody target. Whether an autoantibody or antibody against FLYWCH1 could matter depends on whether native FLYWCH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FLYWCH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FLYWCH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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