Seroatlas · Human Serome Atlas

FBXO48

F-box only protein 48

Also known as: FBX48_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5FWF7
Gene: FBXO48
Ensembl: ENSG00000204923
Chromosome: 2
Canonical length: 155 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

155 residues, UniProt reviewed canonical sequence.

>Q5FWF7|FBXO48
     1  MHKNSKRNNN LRVSHTEANS VDAEKEKNES QNNFFELLPA EITFKIFSQL DIRSLCRASL
    61  TCRSWNDTIR NSDSLWKPHC MTVRAVCRRE IDDDLESGYS WRVILLRNYQ KSKVKHEWLS
   121  GRYSNICSPI SLPEKIMYPM DADTWGEILE AELER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO48 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 2.9 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 2.9 nTPM
retina: 2.8 nTPM
skin: 2.3 nTPM
liver: 1.8 nTPM
duodenum: 1.7 nTPM
tongue: 1.7 nTPM

Single-cell type

early primary spermatocytes: 23 nCPM
platelets: 21 nCPM
esophageal apical cells: 14 nCPM
oocytes: 14 nCPM
plasma cells: 14 nCPM
epididymal principal cells: 12 nCPM

Immune cell

basophil: 2.5 nTPM
T-reg: 2.1 nTPM
memory CD4 T-cell: 1.7 nTPM
neutrophil: 1.4 nTPM
non-classical monocyte: 1.3 nTPM
naive CD4 T-cell: 1.2 nTPM

Brain region

white matter: 6.5 nTPM
basal ganglia: 4.9 nTPM
pons: 4.8 nTPM
cerebral cortex: 4.6 nTPM
thalamus: 4.6 nTPM
medulla oblongata: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: 0.63
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Cellular components

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of FBXO48 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SKP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO48 as an antibody target. Whether an autoantibody or antibody against FBXO48 could matter depends on whether native FBXO48 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO48 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXO48 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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