Seroatlas · Human Serome Atlas

FBXO46

F-box only protein 46

Also known as: 20D7-FC4, Fbx46, FBX46_HUMAN, FBXO34L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PJ61
Gene: FBXO46
Ensembl: ENSG00000177051
Chromosome: 19
Canonical length: 603 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

603 residues, UniProt reviewed canonical sequence.

>Q6PJ61|FBXO46
     1  MDRGSLLPFQ LWCPRPFGTY SQNQPRPPSA ALKPSACPEP GGGAEPDHGP AHSENTPPAL
    61  ATEVPASQPA PLLSAAAAGD EGRVLLDTWY VIKPGNTKEK VAFFVAHQCG GGSRASSMKV
   121  KGHWGSDSSK AKRRRRCLDP TKAPPDPGGR EGPPAAEEGP ASAGEDVDLL SVAEMVALVE
   181  QRAALALQSY PRPTTPAPVV FVSAEQGGPA KGVGSERRSG GGDCSRVAEA VAHFEAQRDS
   241  PPTKGLRKEE RPGPGPGEVR IAFRISNGRE PRAPDSGLPS GGGGRPGCAY PGSPGPGARA
   301  KDKITCDLYQ LISPSRDALP SNVEFLLARA DEASEGDSPA PARPEDTPPA PPPPPARDCG
   361  ASGFHVDVVV TGVVDECIFF GKDGTKNVKE ETVCLTVSPE EPPPPGQLFF LQNRGPDGPP
   421  EPPPADSPAT APGPDDAEGT ADTSLCRLYR HVSHDFLEIR FKIQRLLEPR QYMLLLPEHV
   481  LVKIFSFLPT RALAALKCTC HHFKGIIEAF GVRATDSRWS RDPLYRDDPC KQCRKRYEKG
   541  DVSLCRWHPK PYHHDLPYGR SYWMCCRRAD RETPGCRLGL HDNNWVLPCN GPGGGRAGRE
   601  EGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

esophagus: 20 nTPM
lymph node: 14 nTPM
spleen: 14 nTPM
ovary: 13 nTPM
tonsil: 13 nTPM
endometrium: 13 nTPM

Single-cell type

foveolar cells: 63 nCPM
suprabasal keratinocytes: 53 nCPM
basal keratinocytes: 45 nCPM
extravillous trophoblasts: 39 nCPM
esophageal apical cells: 39 nCPM
neutrophils: 34 nCPM

Immune cell

basophil: 4.6 nTPM
naive B-cell: 3.9 nTPM
neutrophil: 3.2 nTPM
memory B-cell: 2 nTPM
gdT-cell: 1.8 nTPM
naive CD8 T-cell: 1.4 nTPM

Brain region

white matter: 52 nTPM
choroid plexus: 51 nTPM
cerebral cortex: 39 nTPM
hypothalamus: 37 nTPM
pons: 37 nTPM
basal ganglia: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.69
gnomAD missense Z: 2.46
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXO46 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SKP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO46 as an antibody target. Whether an autoantibody or antibody against FBXO46 could matter depends on whether native FBXO46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO46 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXO46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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