FBP2

Protein identityUniProt · HPA

UniProt accession

O00757

Gene

FBP2

Ensembl

ENSG00000130957

Chromosome

9

Canonical length

339 aa

Protein class

Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Plasma membrane,Cytosol

Quaternary structure

Homotetramer

OverviewNCBI Gene

This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>O00757|FBP2
     1  MTDRSPFETD MLTLTRYVME KGRQAKGTGE LTQLLNSMLT AIKAISSAVR KAGLAHLYGI
    61  AGSVNVTGDE VKKLDVLSNS LVINMVQSSY STCVLVSEEN KDAIITAKEK RGKYVVCFDP
   121  LDGSSNIDCL ASIGTIFAIY RKTSEDEPSE KDALQCGRNI VAAGYALYGS ATLVALSTGQ
   181  GVDLFMLDPA LGEFVLVEKD VKIKKKGKIY SLNEGYAKYF DAATTEYVQK KKFPEDGSAP
   241  YGARYVGSMV ADVHRTLVYG GIFLYPANQK SPKGKLRLLY ECNPVAYIIE QAGGLATTGT
   301  QPVLDVKPEA IHQRVPLILG SPEDVQEYLT CVQKNQAGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

706 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FBP2.

Disease | AllUniProt

Conditions FBP2 is implicated in, by any mechanism.

• Leukodystrophy, childhood-onset, remitting (CORLK) MIM:619864

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.99

gnomAD pLI

0

gnomAD missense Z

0.19

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• fructose 1,6-bisphosphate metabolic process
• fructose 6-phosphate metabolic process
• fructose metabolic process
• gluconeogenesis

Molecular functions

• fructose 1,6-bisphosphate 1-phosphatase activity
• identical protein binding
• metal ion binding

Cellular components

• anchoring junction
• cytoplasm
• cytosol
• extracellular exosome
• nucleus
• plasma membrane
• Z disc

Protein domainsUniProt · Pfam · InterPro

• Fructose-1,6-bisphosphatase class 1
• Fructose-1,6-bisphosphatase, active site
• Fructose-1,6-bisphosphatase
• Fructose-1-6-bisphosphatase class I, N-terminal
• Fructose-1-6-bisphosphatase class 1, C-terminal
• Fructose-1-6-bisphosphatase, N-terminal domain
• Fructose-1-6-bisphosphatase, C-terminal domain

KeywordsUniProt

• Allosteric enzyme
• Calcium
• Carbohydrate metabolism
• Cell junction
• Cytoplasm
• Gluconeogenesis
• Hydrolase
• Leukodystrophy
• Magnesium
• Metal-binding
• Nucleus
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of FBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ALDOA
• FBP1