Seroatlas · Human Serome Atlas

FAXC

Failed axon connections homolog

Also known as: C6orf168, dJ273F20, FAXC_HUMAN, MGC2817

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TGI0
Gene: FAXC
Ensembl: ENSG00000146267
Chromosome: 6
Canonical length: 409 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

409 residues, UniProt reviewed canonical sequence.

>Q5TGI0|FAXC
     1  MHWGVGFASS RPCVVDLSWN QSISFFGWWA GSEEPFSFYG DIIAFPLQDY GGIMAGLGSD
    61  PWWKKTLYLT GGALLAAAAY LLHELLVIRK QQEIDSKDAI ILHQFARPNN GVPSLSPFCL
   121  KMETYLRMAD LPYQNYFGGK LSAQGKMPWI EYNHEKVSGT EFIIDFLEEK LGVNLNKNLG
   181  PHERAISRAV TKMVEEHFYW TLAYCQWVDN LNETRKMLSL SGGGPFSNLL RWVVCHITKG
   241  IVKREMHGHG IGRFSEEEIY MLMEKDMRSL AGLLGDKKYI MGPKLSTLDA TVFGHLAQAM
   301  WTLPGTRPER LIKGELINLA MYCERIRRKF WPEWHHDDDN TIYESEESSE GSKTHTPLLD
   361  FSFYSRTETF EDEGAENSFS RTPDTDFTGH SLFDSDVDMD DYTDHEQCK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAXC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

colon: 22 nTPM
cerebral cortex: 20 nTPM
pituitary gland: 15 nTPM
cerebellum: 15 nTPM
urinary bladder: 14 nTPM
hypothalamus: 14 nTPM

Single-cell type

somatotrophs: 99 nCPM
gonadotrophs: 84 nCPM
brain inhibitory neurons: 81 nCPM
pituicytes/fscs: 81 nCPM
brain excitatory neurons: 72 nCPM
thyrotrophs: 69 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 47 nTPM
white matter: 30 nTPM
basal ganglia: 30 nTPM
cerebellum: 26 nTPM
thalamus: 25 nTPM
hypothalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.93
gnomAD missense Z: 1.54
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Thioredoxin-like fold
Metaxin, glutathione S-transferase domain
Thioredoxin-like superfamily
Glutathione S-transferase, C-terminal domain superfamily
Glutathione transferase family
Mitochondrial Protein Transport Metaxin
Glutathione S-transferase, C-terminal domain
FAX/IsoI-like
Failed axon connections homolog, N-terminal domain
Glutathione S-transferase N-terminal domain
Failed axon connections homolog N-terminus

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAXC as an antibody target. Whether an autoantibody or antibody against FAXC could matter depends on whether native FAXC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAXC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAXC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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