Seroatlas · Human Serome Atlas

FAM91A1

Protein FAM91A1

Also known as: F91A1_HUMAN, FLJ23790

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q658Y4
Gene: FAM91A1
Ensembl: ENSG00000176853
Chromosome: 8
Canonical length: 838 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Microtubules

OverviewNCBI Gene

Involved in intracellular protein transport and vesicle tethering to Golgi. Located in cytoplasmic vesicle and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

838 residues, UniProt reviewed canonical sequence.

>Q658Y4|FAM91A1
     1  MNIDVEFHIR HNYPWNKLPA NVRQSLGNSQ REYEKQVVLY SIRNQLRYRN NLVKHVKKDE
    61  RRYYEELLKY SRDHLMLYPY HLSDIMVKGL RITPFSYYTG IMEDIMNSEK SYDSLPNFTA
   121  ADCLRLLGIG RNQYIDLMNQ CRSSKKFFRR KTARDLLPIK PVEIAIEAWW VVQAGYITED
   181  DIKICTLPEK CAVDKIIDSG PQLSGSLDYN VVHSLYNKGF IYLDVPISDD SCIAVPPLEG
   241  FVMNRVQGDY FETLLYKIFV SIDEHTNVAE LANVLEIDLS LVKNAVSMYC RLGFAHKKGQ
   301  VINLDQLHSS WKNVPSVNRL KSTLDPQKML LSWDGGESRS PVQEASSATD TDTNSQEDPA
   361  DTASVSSLSL STGHTKRIAF LFDSTLTAFL MMGNLSPNLK SHAVTMFEVG KLSDESLDSF
   421  LIELEKVQST GEGEAQRYFD HALTLRNTIL FLRHNKDLVA QTAQPDQPNY GFPLDLLRCE
   481  SLLGLDPATC SRVLNKNYTL LVSMAPLTNE IRPVSSCTPQ HIGPAIPEVS SVWFKLYIYH
   541  VTGQGPPSLL LSKGTRLRKL PDIFQSYDRL LITSWGHDPG VVPTSNVLTM LNDALTHSAV
   601  LIQGHGLHGI GETVHVPFPF DETELQGEFT RVNMGVHKAL QILRNRVDLQ HLCGYVTMLN
   661  ASSQLADRKL SDASDERGEP DLASGSDVNG STESFEMVIE EATIDSATKQ TSGATTEADW
   721  VPLELCFGIP LFSSELNRKV CRKIAAHGLC RKESLQNLLH SSRKLSLQVL NFVHSFQEGA
   781  SILDIHTEPS FSSLLSQSSC ADMGVPLPAK NLIFKDGVLS EWSGRSPSSL LIANLHLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM91A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 41 nTPM
liver: 25 nTPM
parathyroid gland: 20 nTPM
placenta: 19 nTPM
spleen: 19 nTPM
lymph node: 18 nTPM

Single-cell type

neutrophils: 257 nCPM
kupffer cells: 162 nCPM
neutrophil progenitors: 152 nCPM
monocytes: 114 nCPM
macrophages: 91 nCPM
gastric progenitor cells: 83 nCPM

Immune cell

eosinophil: 11 nTPM
neutrophil: 10 nTPM
intermediate monocyte: 9.5 nTPM
non-classical monocyte: 8.5 nTPM
myeloid DC: 8.2 nTPM
classical monocyte: 8 nTPM

Brain region

choroid plexus: 31 nTPM
white matter: 29 nTPM
medulla oblongata: 25 nTPM
hypothalamus: 25 nTPM
thalamus: 24 nTPM
spinal cord: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0
gnomAD missense Z: 2.16
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

FAM91, C-terminal domain
FAM91
FAM91 C-terminus
FAM91, N-terminal domain
FAM91 N-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM91A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM91A1 as an antibody target. Whether an autoantibody or antibody against FAM91A1 could matter depends on whether native FAM91A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM91A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM91A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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