Seroatlas · Human Serome Atlas

FAM86B2

Putative protein N-methyltransferase FAM86B2

Also known as: F86B2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C5J1
Gene: FAM86B2
Ensembl: ENSG00000145002
Chromosome: 8
Canonical length: 330 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in methylation. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>P0C5J1|FAM86B2
     1  MAPEENAGTE LLLQGFERRF LAVRTLRSFP WQSLEAKLRD SSDSELLRDI LQKTVRHPVC
    61  VKHPPSVKYA WCFLSELIKK HEAVHTEPLD KLYEVLAETL MAKESTQGHR SYLLSSGGSV
   121  TLSKSTAIIS HGTTGLVTWD AALYLAEWAI ENPAAFINRT VLELGSGAGL TGLAICKMCR
   181  PRAYIFSDPH SRILEQLRGN VLLNGLSLEA DITGNLDSPR VTVAQLDWDV AMVHQLSAFQ
   241  PDVVIAADVL YCPEAIVSLV GVLQRLAACR EHKRAPEVYV AFTVRNPETC QLFTTELGRD
   301  GIRWEAEAHH DQKLFPYGEH LEMAMLNLTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM86B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 0.5 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 0.5 nTPM
pituitary gland: 0.5 nTPM
parathyroid gland: 0.4 nTPM
skin: 0.4 nTPM
basal ganglia: 0.3 nTPM
fallopian tube: 0.3 nTPM

Single-cell type

gonadotrophs: 1.5 nCPM
adrenal cortex cells: 0.9 nCPM
cardiomyocytes: 0.9 nCPM
epididymal principal cells: 0.8 nCPM
fallopian tube ciliated cells: 0.8 nCPM
thyrotrophs: 0.8 nCPM

Immune cell

T-reg: 0.4 nTPM
MAIT T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
myeloid DC: 0.1 nTPM

Brain region

thalamus: 0.4 nTPM
basal ganglia: 0.3 nTPM
cerebral cortex: 0.3 nTPM
hippocampal formation: 0.3 nTPM
midbrain: 0.3 nTPM
pons: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: -2.39
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM86B2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

EEF2KMT

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM86B2 as an antibody target. Whether an autoantibody or antibody against FAM86B2 could matter depends on whether native FAM86B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM86B2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM86B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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