FAM43B
Protein FAM43B
Also known as: FA43B_HUMAN, FLJ44952
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6ZT52
- Gene
- FAM43B
- Ensembl
- ENSG00000183114
- Chromosome
- 1
- Canonical length
- 329 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
No narrative summary is available for FAM43B in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
329 residues, UniProt reviewed canonical sequence.
>Q6ZT52|FAM43B
1 MLPWRRNKFV LVEDEAKCKA KSLSPGLAYT SLLSSFLRSC PDLLPDWPLE RLGRVFRSRR
61 QKVELNKEDP TYTVWYLGNA VTLHAKGDGC TDDAVGKIWA RCGPGGGTKM KLTLGPHGIR
121 MQPCERSAAG GSGGRRPAHA YLLPRITYCT ADGRHPRVFA WVYRHQARHK AVVLRCHAVL
181 LARAHKARAL ARLLRQTALA AFSDFKRLQR QSDARHVRQQ HLRAGGAAAS VPRAPLRRLL
241 NAKCAYRPPP SERSRGAPRL SSIQEEDEEE EEDDAEEQEG GVPQRERPEV LSLARELRTC
301 SLRGAPAPPP PAQPRRWKAG PRERAGQARLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM43B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.52
- Highest tissue expression
- 21 nTPM
Expression across tissuesHPA
Tissue
- adrenal gland: 21 nTPM
- hypothalamus: 15 nTPM
- basal ganglia: 13 nTPM
- cerebellum: 12 nTPM
- midbrain: 11 nTPM
- cerebral cortex: 9.3 nTPM
Single-cell type
- other brain neurons: 13 nCPM
- tuft cells: 12 nCPM
- brain inhibitory neurons: 9 nCPM
- brain excitatory neurons: 6.1 nCPM
- adrenal cortex cells: 4.7 nCPM
- astrocytes: 3.9 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- midbrain: 43 nTPM
- thalamus: 37 nTPM
- medulla oblongata: 32 nTPM
- hypothalamus: 27 nTPM
- pons: 26 nTPM
- cerebral cortex: 24 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.24
- gnomAD pLI
- 0.11
- gnomAD missense Z
- 0.57
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM43B as an antibody target. Whether an autoantibody or antibody against FAM43B could matter depends on whether native FAM43B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM43B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM43B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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