FAM43A
Protein FAM43A
Also known as: FA43A_HUMAN, FLJ90022
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N2R8
- Gene
- FAM43A
- Ensembl
- ENSG00000185112
- Chromosome
- 3
- Canonical length
- 423 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
No narrative summary is available for FAM43A in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
423 residues, UniProt reviewed canonical sequence.
>Q8N2R8|FAM43A
1 MLPWKKHKFE LLAEAPPRQA SKPKGYAVSL HYSALSSLAR ACPEGALSRV GSMFRSKRKK
61 LHITSEDPTY TVLYLGNATT IQARGDGCTD LAVGKIWSKS EAGRQGTKMK LTVSAQGIRM
121 VHAEERALRR PGHLYLLHRV TYCVADARLP KVFAWVYRHE LKHKAVMLRC HAVLVSKPEK
181 AQAMALLLYQ TSANALAEFK RLKRRDDARH QQQELVGAHT IPLVPLRKLL LHGPCCYKPP
241 VERSRSAPKL GSITEDLLGE QLEQELQEEE EEEQPEGCPE EEENRAAEGD PAEEEAEAQR
301 ALVVAMHFEC GDLLDTLENG RGEALGGGGG SLGPGAGPPP LLLGSASDMK AELSQLISDL
361 GELSFGNDVR TLQADLRVTR LLSGDSTGSE SSIEGGGPDA TSATAGDSSR QADGASADEP
421 HSGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM43A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 48 nTPM
Expression across tissuesHPA
Tissue
- spleen: 48 nTPM
- kidney: 29 nTPM
- heart muscle: 26 nTPM
- skin: 24 nTPM
- vagina: 23 nTPM
- adipose tissue: 23 nTPM
Single-cell type
- syncytiotrophoblasts: 204 nCPM
- extravillous trophoblasts: 128 nCPM
- lymphatic endothelial cells: 122 nCPM
- respiratory ionocytes: 102 nCPM
- esophageal apical cells: 98 nCPM
- vascular endothelial cells: 89 nCPM
Immune cell
- plasmacytoid DC: 4.5 nTPM
- naive B-cell: 2.5 nTPM
- basophil: 2.2 nTPM
- NK-cell: 1.6 nTPM
- eosinophil: 1.4 nTPM
- memory B-cell: 1.2 nTPM
Brain region
- pons: 70 nTPM
- medulla oblongata: 37 nTPM
- cerebral cortex: 26 nTPM
- hippocampal formation: 22 nTPM
- midbrain: 17 nTPM
- thalamus: 14 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.67
- gnomAD pLI
- 0.41
- gnomAD missense Z
- 1.49
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM43A as an antibody target. Whether an autoantibody or antibody against FAM43A could matter depends on whether native FAM43A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM43A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM43A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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