Seroatlas · Human Serome Atlas

FAM171A2

Protein FAM171A2

Also known as: F1712_HUMAN, MGC34829

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MVW0
Gene
FAM171A2
Ensembl
ENSG00000161682
Chromosome
17
Canonical length
826 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

826 residues, UniProt reviewed canonical sequence.

>A8MVW0|FAM171A2
     1  MPPASGPSVL ARLLPLLGLL LGSASRAPGK SPPEPPSPQE ILIKVQVYVS GELVPLARAS
    61  VDVFGNRTLL AAGTTDSEGV ATLPLSYRLG TWVLVTAARP GFLTNSVPWR VDKLPLYASV
   121  SLYLLPERPA TLILYEDLVH ILLGSPGARS QPLVQFQRRA ARLPVSSTYS QLWASLTPAS
   181  TQQEMRAFPA FLGTEASSSG NGSWLELMPL TAVSVHLLTG NGTEVPLSGP IHLSLPVPSE
   241  TRALTVGTSI PAWRFDPKSG LWVRNGTGVI RKEGRQLYWT FVSPQLGYWV AAMASPTAGL
   301  VTITSGIQDI GTYHTIFLLT ILAALALLVL ILLCLLIYYC RRRCLKPRQQ HRKLQLSGPS
   361  DGNKRDQATS MSQLHLICGG PLEPAPSGDP EAPPPGPLHS AFSSSRDLAS SRDDFFRTKP
   421  RSASRPAAEP SGARGGESAG LKGARSAEGP GGLEPGLEEH RRGPSGAAAF LHEPPSPPPP
   481  FDHYLGHKGA AEGKTPDFLL SQSVDQLARP PSLGQAGQLI FCGSIDHLKD NVYRNVMPTL
   541  VIPAHYVRLG GEAGAAGVGD EPAPPEGTAP GPARAFPQPD PQRPQMPGHS GPGGEGGGGG
   601  GEGWGAGRAA PVSGSVTIPV LFNESTMAQL NGELQALTEK KLLELGVKPH PRAWFVSLDG
   661  RSNSQVRHSY IDLQAGGGAR STDASLDSGV DVHEARPARR RPAREERERA PPAAPPPPPA
   721  PPRLALSEDT EPSSSESRTG LCSPEDNSLT PLLDEVAAPE GRAATVPRGR GRSRGDSSRS
   781  SASELRRDSL TSPEDELGAE VGDEAGDKKS PWQRREERPL MVFNVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM171A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 16 nTPM
  • cerebellum: 14 nTPM
  • basal ganglia: 10 nTPM
  • amygdala: 9.2 nTPM
  • hippocampal formation: 8.5 nTPM
  • hypothalamus: 8.3 nTPM

Single-cell type

  • müller glia: 144 nCPM
  • retinal horizontal cells: 32 nCPM
  • corticotrophs: 26 nCPM
  • epididymal principal cells: 26 nCPM
  • retinal bipolar cells: 25 nCPM
  • other brain neurons: 23 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 67 nTPM
  • basal ganglia: 53 nTPM
  • amygdala: 46 nTPM
  • hippocampal formation: 44 nTPM
  • white matter: 40 nTPM
  • hypothalamus: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.91
gnomAD missense Z
2.4
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM171A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM171A2 as an antibody target. Whether an autoantibody or antibody against FAM171A2 could matter depends on whether native FAM171A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM171A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM171A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM171A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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