Seroatlas · Human Serome Atlas

FAM169A

Soluble lamin-associated protein of 75 kDa

Also known as: F169A_HUMAN, KIAA0888, SLAP75

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6X4
Gene
FAM169A
Ensembl
ENSG00000198780
Chromosome
5
Canonical length
670 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear membrane,Cytosol

OverviewNCBI Gene

Predicted to be located in nuclear inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

670 residues, UniProt reviewed canonical sequence.

>Q9Y6X4|FAM169A
     1  MAFPVDMLEN CSHEELENSA EDYMSDLRCG DPENPECFSL LNITIPISLS NVGFVPLYGG
    61  DQTQKILALF APEDSLTAVA LYLADQWWAI DDIVKTSVPS REGLKQVSTL GERVVLYVLN
   121  RIIYRKQEME RNEIPFLCHS STDYAKILWK KGEAIGFYSV KPTGSICASF LTQSYQLPVL
   181  DTMFLRKKYR GKDFGLHMLE DFVDSFTEDA LGLRYPLSSL MYTACKQYFE KYPGDHELLW
   241  EVEGVGHWYQ RIPVTRALQR EALKILALSQ NEPKRPMSGE YGPASVPEYE ARTEDNQSSE
   301  MQLTIDSLKD AFASTSEGHD KTSVSTHTRS GNLKRPKIGK RFQDSEFSSS QGEDEKTSQT
   361  SLTASINKLE STARPSESSE EFLEEEPEQR GIEFEDESSD RDARPALETQ PQQEKQDGEK
   421  ESELEPMNGE IMDDSLKTSL ITEEEDSTSE VLDEELKLQP FNSSEDSTNL VPLVVESSKP
   481  PEVDAPDKTP RIPDSEMLMD EGTSDEKGHM EEKLSLLPRK KAHLGSSDNV ATMSNEERSD
   541  GGFPNSVIAE FSEEPVSENL SPNTTSSLED QGEEGVSEPQ ETSTALPQSS LIEVELEDVP
   601  FSQNAGQKNQ SEEQSEASSE QLDQFTQSAE KAVDSSSEEI EVEVPVVDRR NLRRKAKGHK
   661  GPAKKKAKLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM169A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • retina: 73 nTPM
  • epididymis: 18 nTPM
  • cerebral cortex: 15 nTPM
  • testis: 11 nTPM
  • thyroid gland: 6.3 nTPM
  • parathyroid gland: 5.1 nTPM

Single-cell type

  • rod photoreceptor cells: 732 nCPM
  • müller glia: 438 nCPM
  • cone photoreceptor cells: 383 nCPM
  • retinal bipolar cells: 299 nCPM
  • retinal amacrine cells: 247 nCPM
  • retinal horizontal cells: 188 nCPM

Immune cell

  • MAIT T-cell: 1.1 nTPM
  • naive CD8 T-cell: 1 nTPM
  • naive CD4 T-cell: 0.8 nTPM
  • gdT-cell: 0.7 nTPM
  • memory CD8 T-cell: 0.7 nTPM
  • memory CD4 T-cell: 0.4 nTPM

Brain region

  • hypothalamus: 78 nTPM
  • thalamus: 61 nTPM
  • spinal cord: 60 nTPM
  • white matter: 60 nTPM
  • medulla oblongata: 55 nTPM
  • basal ganglia: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
1
gnomAD missense Z
1.42
DepMap mean gene effect
-0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM169A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM169A as an antibody target. Whether an autoantibody or antibody against FAM169A could matter depends on whether native FAM169A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM169A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM169A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM169A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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