Seroatlas · Human Serome Atlas

FAM168B

Myelin-associated neurite-outgrowth inhibitor

Also known as: F168B_HUMAN, KIAA0280L, MANI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1KXE4
Gene: FAM168B
Ensembl: ENSG00000152102
Chromosome: 2
Canonical length: 195 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to act upstream of or within axonogenesis and gene expression. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

195 residues, UniProt reviewed canonical sequence.

>A1KXE4|FAM168B
     1  MNPVYSPGSS GVPYANAKGI GYPAGFPMGY AAAAPAYSPN MYPGANPTFQ TGYTPGTPYK
    61  VSCSPTSGAV PPYSSSPNPY QTAVYPVRSA YPQQSPYAQQ GTYYTQPLYA APPHVIHHTT
   121  VVQPNGMPAT VYPAPIPPPR GNGVTMGMVA GTTMAMSAGT LLTAHSPTPV APHPVTVPTY
   181  RAPGTPTYSY VPPQW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM168B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 64 nTPM
cerebral cortex: 61 nTPM
skeletal muscle: 57 nTPM
cerebellum: 55 nTPM
amygdala: 50 nTPM
tongue: 49 nTPM

Single-cell type

rod photoreceptor cells: 136 nCPM
myonuclei: 131 nCPM
cone photoreceptor cells: 116 nCPM
neutrophils: 112 nCPM
endometrial glandular cells: 111 nCPM
renal collecting duct intercalated cells: 108 nCPM

Immune cell

naive CD4 T-cell: 4.8 nTPM
gdT-cell: 4.4 nTPM
eosinophil: 4.3 nTPM
MAIT T-cell: 4 nTPM
memory CD4 T-cell: 3.7 nTPM
memory CD8 T-cell: 3.7 nTPM

Brain region

basal ganglia: 113 nTPM
thalamus: 102 nTPM
cerebral cortex: 92 nTPM
hippocampal formation: 90 nTPM
spinal cord: 89 nTPM
amygdala: 89 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0.02
gnomAD missense Z: 1.27
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM168B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CDC27

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM168B as an antibody target. Whether an autoantibody or antibody against FAM168B could matter depends on whether native FAM168B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM168B is annotated at the cell surface, where native FAM168B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FAM168B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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