Seroatlas · Human Serome Atlas

FAM117A

Protein FAM117A

Also known as: F117A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C073
Gene: FAM117A
Ensembl: ENSG00000121104
Chromosome: 17
Canonical length: 453 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for FAM117A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>Q9C073|FAM117A
     1  MAGAAAGGRG GGAWGPGRGG AGGLRRGCSP PAPAGSPRAG LQPLRATIPF QLQQPHQRRD
    61  GGGRAASVPC SVAPEKSVCR PQPLQVRRTF SLDTILSSYL LGQWPRDADG AFTCCTNDKA
   121  TQTPLSWQEL EGERASSCAH KRSASWGSTD HRKEISKLKQ QLQRTKLSRS GKEKERGSPL
   181  LGDHAVRGAL RASPPSFPSG SPVLRLSPCL HRSLEGLNQE LEEVFVKEQG EEELLRILDI
   241  PDGHRAPAPP QSGSCDHPLL LLEPGNLASS PSMSLASPQP CGLASHEEHR GAAEELASTP
   301  NDKASSPGHP AFLEDGSPSP VLAFAASPRP NHSYIFKREP PEGCEKVRVF EEATSPGPDL
   361  AFLTSCPDKN KVHFNPTGSA FCPVNLMKPL FPGMGFIFRN CPSNPGSPLP PASPRPPPRK
   421  DPEASKASPL PFEPWQRTPP SEEPVLFQSS LMV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM117A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 72 nTPM
choroid plexus: 67 nTPM
spleen: 33 nTPM
blood vessel: 23 nTPM
colon: 22 nTPM
thymus: 22 nTPM

Single-cell type

megakaryocyte-erythroid progenitors: 255 nCPM
hematopoietic stem cells: 207 nCPM
choroid plexus epithelial cells: 194 nCPM
thymocytes: 169 nCPM
erythrocyte progenitors: 168 nCPM
nk-cells: 103 nCPM

Immune cell

basophil: 51 nTPM
memory B-cell: 24 nTPM
naive B-cell: 15 nTPM
NK-cell: 13 nTPM
MAIT T-cell: 9.2 nTPM
eosinophil: 9.1 nTPM

Brain region

choroid plexus: 77 nTPM
cerebellum: 18 nTPM
hippocampal formation: 16 nTPM
amygdala: 12 nTPM
basal ganglia: 11 nTPM
hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 1.49
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM117A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM117A as an antibody target. Whether an autoantibody or antibody against FAM117A could matter depends on whether native FAM117A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM117A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM117A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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