Seroatlas · Human Serome Atlas

EXOC3L4

Exocyst complex component 3-like protein 4

Also known as: C14orf73, EX3L4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q17RC7
Gene: EXOC3L4
Ensembl: ENSG00000205436
Chromosome: 14
Canonical length: 722 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable SNARE binding activity. Predicted to be involved in exocyst localization and exocytosis. Predicted to be part of exocyst. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

722 residues, UniProt reviewed canonical sequence.

>Q17RC7|EXOC3L4
     1  MPSPQTDTPG PELQSPKEAE EPQTPAQGSR RTSSRKEPNA HRKDGTRLGL GSLRQAFSRA
    61  SQRALTQVSK EDTGLFRRSS CSLFRSFRQA LNDGPATGHS QATPEVPSGV MNGVSQQAST
   121  GAASEELKPE AEGKSVADLI TERQLLAAFE QLLRLETLLV AEKASRTFEQ DPTAFARRAM
   181  DVCLLYDGLA AEIGAIVRET LDSDGVDAAA LAELARVVSA EEEAHPSPPD DGDFLRTPRR
   241  WRQHWEEAVR RSAQERVRRP GAGWAFGEAE GASGLAQLLA ELGGLVRRDL QKVRQEVQPA
   301  YAAAGFPAWE VYLRAFHSAV AQRLQELARD ARGCEQLYIL LDWAANVYGS PDFLGAPGLA
   361  LPAEPLPPLL APDVWARLES DYTSFLEAKI ASCFDSILQL EQSHWAAAEV PEVLQGLYQA
   421  PLSMDVHMLV AEHVKAAGAI SAELEATTLR ICTRALGLFV PRFEKAFLAS EAVSEPHLGA
   481  YINACEELRT SLLSRFPGTQ EELEKPLVTA TCSFQKHLLQ GLQRELQPLF RVVCTRDWLT
   541  QDWLHPLMDK VVTFAGHLQR VARPRAQETL QEVHRFVVRE YLARALRPRE RFRGMERMHG
   601  SQKMSLDAQA ISDTFQGLGS EATWLDQAIQ CVAEILGETY KDDIQRHLET LIRSYPDIRR
   661  DHILAILALR RLGRQRNQHL LQHTQDLLRA AAGAAGAEAP RGRVLFEEIK VPSAMAVLIT
   721  CV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXOC3L4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

liver: 21 nTPM
duodenum: 17 nTPM
small intestine: 8.6 nTPM
spleen: 4.8 nTPM
stomach: 4.5 nTPM
lymph node: 4.3 nTPM

Single-cell type

enterocytes: 91 nCPM
megakaryocytes: 62 nCPM
tuft cells: 46 nCPM
proximal tubule cells: 45 nCPM
hepatocytes: 42 nCPM
mucous neck cells: 30 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
choroid plexus: 0.2 nTPM
amygdala: 0.1 nTPM
hippocampal formation: 0.1 nTPM
medulla oblongata: 0.1 nTPM
basal ganglia: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.69
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

SNARE binding

Cellular components

exocyst

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EXOC3L4 as an antibody target. Whether an autoantibody or antibody against EXOC3L4 could matter depends on whether native EXOC3L4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EXOC3L4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EXOC3L4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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