Seroatlas · Human Serome Atlas

EXOC3L2

Exocyst complex component 3-like protein 2

Also known as: EX3L2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2M3D2
Gene: EXOC3L2
Canonical length: 802 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for EXOC3L2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

802 residues, UniProt reviewed canonical sequence.

>Q2M3D2|EXOC3L2
     1  MPILKNLGVS DPKVPRAGTL PLRSSRNPFE EVSGLEEEEA GELGSLPNGT SCRRRATLEK
    61  LAGLAPFRLG WAPGRRAGSP GDGQPRSFLG RVLVPGIRRS SADFGLLARL HGTRAHGDEE
   121  AAGEAARRLA FLRLGRGSKP QRASLAERVV PAGEAAPEPP PKVPEPPKMK EPLSVLEILS
   181  LIQQRELARA DEHILELEAE ELAPSRGGAP GPPKAEGAGG GRRARDVALL YEALQRELWA
   241  LVRETLAGPG PGACAGAGAV AQLGQVLVQE EAADGRRGPG AARKLRARWA EAVARAARER
   301  LEAAAPGAPG GLAGQLEALR ARLLEDMAVV RGRLAPAYPA GLGAFGVYLR GYHGALAEWL
   361  GASARRRLPL ADRYALLHWH NQVYPREVLG LVDMAALENG ELGPLLSPGT LRGLEDECVT
   421  DVKAQTRAAL LRVLQEDEEH WGSLEDQPSS LAQDVCELLE EHTERAPRIS QEFGERMAHC
   481  CLGGLAEFLQ SFQQRVERFH ENPAVREMLP DTYISKTIAL VNCGPPLRAL AERLARVGPP
   541  ESEPAREASA SALDHVTRLC HRVVANLLFQ ELQPHFNKLM RRKWLSSPEA LDGIVGTLGA
   601  QALALRRMQD EPYQALVAEL HRRALVEYVR PLLRGRLRCS SARTRSRVAG RLREDAAQLQ
   661  RLFRRLESQA SWLDAVVPHL AEVMQLEDTP SIQVEVGVLV RDYPDIRQKH VAALLDIRGL
   721  RNTAARQEIL AVARDLELSE EGALSPPRDR AFFADIPVPR PSFCLSLPLF LGRLPLSRLA
   781  RPSLACLPRP RPPSLARPRA QR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXOC3L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

kidney: 21 nTPM
thyroid gland: 18 nTPM
adrenal gland: 9 nTPM
spleen: 8.7 nTPM
pituitary gland: 5.4 nTPM
prostate: 5.3 nTPM

Single-cell type

megakaryocytes: 80 nCPM
vascular endothelial cells: 60 nCPM
oocytes: 46 nCPM
platelets: 33 nCPM
megakaryocyte progenitors: 27 nCPM
undifferentiated spermatogonia: 17 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.3 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 4.8 nTPM
medulla oblongata: 3 nTPM
basal ganglia: 2.7 nTPM
white matter: 2.7 nTPM
midbrain: 2.6 nTPM
pons: 2.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EXOC3L2.

Disease | AllUniProt

Conditions EXOC3L2 is implicated in, by any mechanism.

Brain malformation renal syndrome (BMRS) MIM:620943

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 138 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Meckel-Gruber syndrome
Brain malformation renal syndrome
Meckel-like syndrome
EXOC3L2-related brain malformations and/or renal disease

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.76
gnomAD missense Z: 0.66
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

exocytosis

Cellular components

exocyst

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EXOC3L2 as an antibody target. Whether an autoantibody or antibody against EXOC3L2 could matter depends on whether native EXOC3L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EXOC3L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EXOC3L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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