Seroatlas · Human Serome Atlas

ETNPPL

Ethanolamine-phosphate phospho-lyase

Also known as: AGXT2L1, AT2L1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TBG4
Gene
ETNPPL
Ensembl
ENSG00000164089
Chromosome
4
Canonical length
499 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homotetramer

OverviewNCBI Gene

Enables ethanolamine-phosphate phospho-lyase activity. Predicted to act upstream of or within several processes, including cellular response to glucocorticoid stimulus; ceramide phosphoethanolamine catabolic process; and phospholipid transfer to membrane. Predicted to be located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

499 residues, UniProt reviewed canonical sequence.

>Q8TBG4|ETNPPL
     1  MCELYSKRDT LGLRKKHIGP SCKVFFASDP IKIVRAQRQY MFDENGEQYL DCINNVAHVG
    61  HCHPGVVKAA LKQMELLNTN SRFLHDNIVE YAKRLSATLP EKLSVCYFTN SGSEANDLAL
   121  RLARQFRGHQ DVITLDHAYH GHLSSLIEIS PYKFQKGKDV KKEFVHVAPT PDTYRGKYRE
   181  DHADSASAYA DEVKKIIEDA HNSGRKIAAF IAESMQSCGG QIIPPAGYFQ KVAEYVHGAG
   241  GVFIADEVQV GFGRVGKHFW SFQMYGEDFV PDIVTMGKPM GNGHPVACVV TTKEIAEAFS
   301  SSGMEYFNTY GGNPVSCAVG LAVLDIIENE DLQGNAKRVG NYLTELLKKQ KAKHTLIGDI
   361  RGIGLFIGID LVKDHLKRTP ATAEAQHIIY KMKEKRVLLS ADGPHRNVLK IKPPMCFTEE
   421  DAKFMVDQLD RILTVLEEAM GTKTESVTSE NTPCKTKMLK EAHIELLRDS TTDSKENPSR
   481  KRNGMCTDTH SLLSKRLKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ETNPPL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
265 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 265 nTPM
  • amygdala: 263 nTPM
  • liver: 179 nTPM
  • cerebral cortex: 177 nTPM
  • midbrain: 143 nTPM
  • hippocampal formation: 112 nTPM

Single-cell type

  • astrocytes: 514 nCPM
  • bergmann glia: 176 nCPM
  • parietal cells: 118 nCPM
  • salivary acinar cells: 40 nCPM
  • hepatocytes: 34 nCPM
  • salivary myoepithelial cells: 18 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 239 nTPM
  • amygdala: 237 nTPM
  • hypothalamus: 223 nTPM
  • cerebral cortex: 191 nTPM
  • hippocampal formation: 172 nTPM
  • midbrain: 165 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
gnomAD missense Z
1.73
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ETNPPL as an antibody target. Whether an autoantibody or antibody against ETNPPL could matter depends on whether native ETNPPL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ETNPPL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ETNPPL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ETNPPL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...