Aminotransferase class-III
IPR005814
Definition
Aminotransferases share certain mechanistic features with other pyridoxalphosphate-dependent enzymes, such as the covalent binding of the pyridoxalphosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped into subfamilies PMID:1618757. One of these, called class-III, includes: Acetylornithine aminotransferase ([ec:2.6.1.11]), which catalyses the transfer of an amino group from acetylornithine to alpha-ketoglutarate, yielding N-acetyl-glutamic-5-semi-aldehyde and glutamic acid PMID:2199330; Ornithine aminotransferase ([ec:2.6.1.13]), which catalyses the transfer of an amino group from ornithine to alpha-ketoglutarate, yielding glutamic-5-semi-aldehyde and glutamic acid PMID:3754226; Omega-amino acid--pyruvate aminotransferase ([ec:2.6.1.18]), which catalyses transamination between a variety of omega-amino acids, mono-and diamines, and pyruvate PMID:2500426; 4-aminobutyrate aminotransferase ([ec:2.6.1.19]) (GABA transaminase), which catalyses the transfer of an amino group from GABA to alpha-ketoglutarate, yielding succinate semialdehyde and glutamic acid PMID:10989446; DAPA aminotransferase ([ec:2.6.1.62]), a bacterial enzyme (bioA), which catalyses an intermediate step in the biosynthesis of biotin, the transamination of 7-keto-8-aminopelargonic acid to form 7,8-diaminopelargonic acid PMID:1092681; 2,2-dialkylglycine decarboxylase ([ec:4.1.1.64]), a Burkholderia cepacia (Pseudomonas cepacia) enzyme (dgdA) that catalyses the decarboxylating amino transfer of 2,2-dialkylglycine and pyruvate to dialkyl ketone, alanine and carbon dioxide PMID:8342040; Glutamate-1-semialdehyde aminotransferase ([ec:5.4.3.8]) (GSA) PMID:2349227; Bacillus subtilis aminotransferases yhxA and yodT; Haemophilus influenzae diaminobutyrate--2-oxoglutarate aminotransferase (HI0949) PMID:9514614; Caenorhabditis elegans alanine--glyoxylate aminotransferase 2-like (T01B11.2).
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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