ERP29

Protein identityUniProt · HPA

UniProt accession

P30040

Gene

ERP29

Ensembl

ENSG00000089248

Chromosome

12

Canonical length

261 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Microtubules

Secretome location

Intracellular and membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a protein which localizes to the lumen of the endoplasmic reticulum (ER). It is a member of the protein disulfide isomerase (PDI) protein family but lacks an active thioredoxin motif, suggesting that this protein does not function as a disulfide isomerase. The canonical protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>P30040|ERP29
     1  MAAAVPRAAF LSPLLPLLLG FLLLSAPHGG SGLHTKGALP LDTVTFYKVI PKSKFVLVKF
    61  DTQYPYGEKQ DEFKRLAENS ASSDDLLVAE VGISDYGDKL NMELSEKYKL DKESYPVFYL
   121  FRDGDFENPV PYTGAVKVGA IQRWLKGQGV YLGMPGCLPV YDALAGEFIR ASGVEARQAL
   181  LKQGQDNLSS VKETQKKWAE QYLKIMGKIL DQGEDFPASE MTRIARLIEK NKMSDGKKEE
   241  LQKSLNILTA FQKKGAEKEE L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERP29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

255 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ERP29.

Disease | ImmuneIEDB

Conditions an epitope on ERP29 was assayed in.

• narcolepsy B cell
• multiple sclerosis B cell
• peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.53

gnomAD pLI

0.75

gnomAD missense Z

0.18

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• intracellular protein transport
• negative regulation of gene expression
• negative regulation of protein secretion
• positive regulation of gene expression
• positive regulation of MAPK cascade
• protein folding
• protein secretion
• protein unfolding
• regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Molecular functions

• protein homodimerization activity
• protein-folding chaperone binding

Cellular components

• cell surface
• endoplasmic reticulum
• endoplasmic reticulum lumen
• melanosome
• membrane
• smooth endoplasmic reticulum

Protein domainsUniProt · Pfam · InterPro

• Thioredoxin-like superfamily
• Endoplasmic reticulum resident protein 29, C-terminal
• ERp29, N-terminal
• Endoplasmic reticulum resident protein 29
• Endoplasmic reticulum resident protein 29, C-terminal domain superfamily
• Endoplasmic reticulum protein ERp29, C-terminal domain
• ERp29, N-terminal domain

KeywordsUniProt

• Endoplasmic reticulum
• Phosphoprotein
• Signal