Seroatlas · Human Serome Atlas

ERP27

Endoplasmic reticulum resident protein 27

Also known as: C12orf46, ERP27_HUMAN, FLJ32115, PDIA8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DN0
Gene: ERP27
Ensembl: ENSG00000139055
Chromosome: 12
Canonical length: 273 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a noncatalytic member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. The canonical protein has an N-terminal signal sequence, two thioredoxin (TRX)-like domains and a C-terminal ER-retention sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which lack domains present in the canonical protein. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>Q96DN0|ERP27
     1  MEAAPSRFMF LLFLLTCELA AEVAAEVEKS SDGPGAAQEP TWLTDVPAAM EFIAATEVAV
    61  IGFFQDLEIP AVPILHSMVQ KFPGVSFGIS TDSEVLTHYN ITGNTICLFR LVDNEQLNLE
   121  DEDIESIDAT KLSRFIEINS LHMVTEYNPV TVIGLFNSVI QIHLLLIMNK ASPEYEENMH
   181  RYQKAAKLFQ GKILFILVDS GMKENGKVIS FFKLKESQLP ALAIYQTLDD EWDTLPTAEV
   241  SVEHVQNFCD GFLSGKLLKE NRESEGKTPK VEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERP27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 1,700 nTPM

Expression across tissuesHPA

Tissue

pancreas: 1,700 nTPM
fallopian tube: 73 nTPM
kidney: 27 nTPM
urinary bladder: 17 nTPM
lung: 11 nTPM
thyroid gland: 8.9 nTPM

Single-cell type

pancreatic acinar cells: 318 nCPM
epididymal clear cells: 180 nCPM
fallopian tube ciliated cells: 160 nCPM
fallopian secretory cells: 124 nCPM
transitional alveolar cells: 55 nCPM
endometrial ciliated cells: 51 nCPM

Immune cell

MAIT T-cell: 6.3 nTPM
naive CD8 T-cell: 5.9 nTPM
T-reg: 5.9 nTPM
naive CD4 T-cell: 5.5 nTPM
gdT-cell: 4.8 nTPM
non-classical monocyte: 4.6 nTPM

Brain region

cerebral cortex: 6.6 nTPM
amygdala: 5.8 nTPM
basal ganglia: 4 nTPM
hippocampal formation: 3.9 nTPM
medulla oblongata: 3.9 nTPM
pons: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: -0.4
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ERP27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERP27 as an antibody target. Whether an autoantibody or antibody against ERP27 could matter depends on whether native ERP27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERP27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERP27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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