Seroatlas · Human Serome Atlas

EREG

Proepiregulin

Also known as: ER, EREG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14944
Gene
EREG
Ensembl
ENSG00000124882
Chromosome
4
Canonical length
169 aa
Protein class
Human disease related genes, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Vesicles,Cytosol
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

169 residues, UniProt reviewed canonical sequence.

>O14944|EREG
     1  MTAGRRMEML CAGRVPALLL CLGFHLLQAV LSTTVIPSCI PGESSDNCTA LVQTEDNPRV
    61  AQVSITKCSS DMNGYCLHGQ CIYLVDMSQN YCRCEVGYTG VRCEHFFLTV HQPLSKEYVA
   121  LTVILIILFL ITVVGSTYYF CRWYRNRKSK EPKKEYERVT SGDPELPQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EREG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
122 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 122 nTPM
  • esophagus: 12 nTPM
  • appendix: 9.6 nTPM
  • skin: 8.8 nTPM
  • gallbladder: 5.2 nTPM
  • urinary bladder: 4.6 nTPM

Single-cell type

  • monocytes: 3,369 nCPM
  • monocyte progenitors: 3,243 nCPM
  • megakaryocyte-erythroid progenitors: 1,195 nCPM
  • hematopoietic stem cells: 948 nCPM
  • megakaryocyte progenitors: 935 nCPM
  • esophageal apical cells: 833 nCPM

Immune cell

  • eosinophil: 0.5 nTPM
  • basophil: 0.4 nTPM
  • classical monocyte: 0.2 nTPM
  • intermediate monocyte: 0.2 nTPM
  • myeloid DC: 0.2 nTPM
  • neutrophil: 0.1 nTPM

Brain region

  • thalamus: 1.7 nTPM
  • pons: 1.4 nTPM
  • cerebral cortex: 1.3 nTPM
  • choroid plexus: 1.3 nTPM
  • hippocampal formation: 1.2 nTPM
  • hypothalamus: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.57
gnomAD pLI
0
gnomAD missense Z
-0.37
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EREG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EREG as an antibody target. Whether an autoantibody or antibody against EREG could matter depends on whether native EREG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EREG is annotated at the cell surface, where native EREG is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EREG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EREG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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