Seroatlas · Human Serome Atlas

ENTPD6

Ectonucleoside triphosphate diphosphohydrolase 6

Also known as: CD39L2, dJ738P15.3, ENTP6_HUMAN, IL6ST2, NTPDase-6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75354
Gene
ENTPD6
Ensembl
ENSG00000197586
Chromosome
20
Canonical length
484 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Golgi apparatus
Secretome location
Secreted to blood

OverviewNCBI Gene

ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

484 residues, UniProt reviewed canonical sequence.

>O75354|ENTPD6
     1  MKKGIRYETS RKTSYIFQQP QHGPWQTRMR KISNHGSLRV AKVAYPLGLC VGVFIYVAYI
    61  KWHRATATQA FFSITRAAPG ARWGQQAHSP LGTAADGHEV FYGIMFDAGS TGTRVHVFQF
   121  TRPPRETPTL THETFKALKP GLSAYADDVE KSAQGIRELL DVAKQDIPFD FWKATPLVLK
   181  ATAGLRLLPG EKAQKLLQKV KKVFKASPFL VGDDCVSIMN GTDEGVSAWI TINFLTGSLK
   241  TPGGSSVGML DLGGGSTQIA FLPRVEGTLQ ASPPGYLTAL RMFNRTYKLY SYSYLGLGLM
   301  SARLAILGGV EGQPAKDGKE LVSPCLSPSF KGEWEHAEVT YRVSGQKAAA SLHELCAARV
   361  SEVLQNRVHR TEEVKHVDFY AFSYYYDLAA GVGLIDAEKG GSLVVGDFEI AAKYVCRTLE
   421  TQPQSSPFSC MDLTYVSLLL QEFGFPRSKV LKLTRKIDNV ETSWALGAIF HYIDSLNRQK
   481  SPAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENTPD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
117 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 117 nTPM
  • cerebral cortex: 92 nTPM
  • cerebellum: 87 nTPM
  • heart muscle: 72 nTPM
  • salivary gland: 67 nTPM
  • hypothalamus: 63 nTPM

Single-cell type

  • late spermatids: 115 nCPM
  • colonocytes: 83 nCPM
  • tuft cells: 81 nCPM
  • peritubular myoid cells: 77 nCPM
  • cytotrophoblasts: 76 nCPM
  • cardiomyocytes: 72 nCPM

Immune cell

  • myeloid DC: 27 nTPM
  • MAIT T-cell: 26 nTPM
  • classical monocyte: 25 nTPM
  • total PBMC: 22 nTPM
  • gdT-cell: 19 nTPM
  • plasmacytoid DC: 19 nTPM

Brain region

  • basal ganglia: 146 nTPM
  • cerebral cortex: 132 nTPM
  • hippocampal formation: 128 nTPM
  • hypothalamus: 117 nTPM
  • amygdala: 113 nTPM
  • pons: 109 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
gnomAD missense Z
0.77
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ENTPD6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENTPD6 as an antibody target. Whether an autoantibody or antibody against ENTPD6 could matter depends on whether native ENTPD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENTPD6 is annotated at the cell surface, where native ENTPD6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ENTPD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ENTPD6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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