Seroatlas · Human Serome Atlas

EMP3

Epithelial membrane protein 3

Also known as: EMP3_HUMAN, YMP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P54852
Gene: EMP3
Ensembl: ENSG00000142227
Chromosome: 19
Canonical length: 163 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the PMP-22/EMP/MP20 family of proteins. The protein contains four transmembrane domains and two N-linked glycosylation sites. It is thought to be involved in cell proliferation, cell-cell interactions and function as a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

163 residues, UniProt reviewed canonical sequence.

>P54852|EMP3
     1  MSLLLLVVSA LHILILILLF VATLDKSWWT LPGKESLNLW YDCTWNNDTK TWACSNVSEN
    61  GWLKAVQVLM VLSLILCCLS FILFMFQLYT MRRGGLFYAT GLCQLCTSVA VFTGALIYAI
   121  HAEEILEKHP RGGSFGYCFA LAWVAFPLAL VSGIIYIHLR KRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EMP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 306 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 306 nTPM
colon: 215 nTPM
blood vessel: 199 nTPM
endometrium: 198 nTPM
cervix: 193 nTPM
smooth muscle: 189 nTPM

Single-cell type

melanocytes: 1,041 nCPM
platelets: 891 nCPM
monocytes: 817 nCPM
cdc: 752 nCPM
decidual stromal cells: 699 nCPM
mast cells: 673 nCPM

Immune cell

basophil: 2,415 nTPM
total PBMC: 1,974 nTPM
T-reg: 1,637 nTPM
memory CD4 T-cell: 1,430 nTPM
eosinophil: 1,407 nTPM
gdT-cell: 1,328 nTPM

Brain region

hypothalamus: 60 nTPM
medulla oblongata: 55 nTPM
white matter: 46 nTPM
spinal cord: 38 nTPM
thalamus: 37 nTPM
midbrain: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0
gnomAD missense Z: 0.63
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

PMP-22/EMP/MP20/Claudin
PMP-22/EMP/MP20
Peripheral myelin protein 22/Epithelial membrane protein-like
PMP-22/EMP/MP20/Claudin family
Epithelial membrane protein EMP-3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EMP3 as an antibody target. Whether an autoantibody or antibody against EMP3 could matter depends on whether native EMP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EMP3 is annotated at the cell surface, where native EMP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EMP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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