Seroatlas · Human Serome Atlas

EMP1

Epithelial membrane protein 1

Also known as: CL-20, EMP1_HUMAN, TMP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P54849
Gene
EMP1
Ensembl
ENSG00000134531
Chromosome
12
Canonical length
157 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Involved in apoptotic process and bleb assembly. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

157 residues, UniProt reviewed canonical sequence.

>P54849|EMP1
     1  MLVLLAGIFV VHIATVIMLF VSTIANVWLV SNTVDASVGL WKNCTNISCS DSLSYASEDA
    61  LKTVQAFMIL SIIFCVIALL VFVFQLFTME KGNRFFLSGA TTLVCWLCIL VGVSIYTSHY
   121  ANRDGTQYHH GYSYILGWIC FCFSFIIGVL YLVLRKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EMP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
1,936 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 1,936 nTPM
  • vagina: 706 nTPM
  • adipose tissue: 502 nTPM
  • cervix: 431 nTPM
  • salivary gland: 287 nTPM
  • gallbladder: 192 nTPM

Single-cell type

  • esophageal apical cells: 30,858 nCPM
  • ocular epithelial cells: 4,391 nCPM
  • suprabasal keratinocytes: 2,192 nCPM
  • esophageal suprabasal cells: 2,067 nCPM
  • breast secretory cells: 1,312 nCPM
  • basal keratinocytes: 1,263 nCPM

Immune cell

  • myeloid DC: 3.5 nTPM
  • plasmacytoid DC: 0.4 nTPM
  • classical monocyte: 0.2 nTPM
  • intermediate monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • hypothalamus: 82 nTPM
  • medulla oblongata: 44 nTPM
  • pons: 38 nTPM
  • spinal cord: 36 nTPM
  • midbrain: 31 nTPM
  • white matter: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0.5
gnomAD missense Z
0.1
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EMP1 as an antibody target. Whether an autoantibody or antibody against EMP1 could matter depends on whether native EMP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EMP1 is annotated at the cell surface, where native EMP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EMP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EMP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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