EIF1AY
Eukaryotic translation initiation factor 1A, Y-chromosomal
Also known as: IF1AY_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O14602
- Gene
- EIF1AY
- Ensembl
- ENSG00000198692
- Chromosome
- Y
- Canonical length
- 144 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Canonical amino-acid sequenceUniProt
144 residues, UniProt reviewed canonical sequence.
>O14602|EIF1AY
1 MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAL CFDGVKRLCH
61 IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT
121 FGPGDDDEIQ FDDIGDDDED IDDILocalizationUniProt · AlphaFold · HPA
Whether an antibody against EIF1AY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 123 nTPM
Expression across tissuesHPA
Tissue
- tongue: 123 nTPM
- heart muscle: 114 nTPM
- skeletal muscle: 82 nTPM
- bone marrow: 56 nTPM
- spleen: 31 nTPM
- kidney: 30 nTPM
Single-cell type
- cytotrophoblasts: 155 nCPM
- erythrocyte progenitors: 132 nCPM
- erythrocytes: 127 nCPM
- migrating cytotrophoblasts: 113 nCPM
- gastric progenitor cells: 105 nCPM
- parietal cells: 104 nCPM
Immune cell
- neutrophil: 126 nTPM
- plasmacytoid DC: 66 nTPM
- naive B-cell: 55 nTPM
- memory B-cell: 53 nTPM
- basophil: 49 nTPM
- T-reg: 32 nTPM
Brain region
- white matter: 6.1 nTPM
- hypothalamus: 6 nTPM
- midbrain: 6 nTPM
- pons: 5.8 nTPM
- medulla oblongata: 5.7 nTPM
- cerebellum: 4.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.18
- gnomAD pLI
- 0.55
- gnomAD missense Z
- 1.03
- DepMap mean gene effect
- -0.24
- DepMap dependency class
- selective
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of EIF1AY in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads EIF1AY as an antibody target. Whether an autoantibody or antibody against EIF1AY could matter depends on whether native EIF1AY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
EIF1AY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label EIF1AY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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