EIF1AX

Protein identityUniProt · HPA

UniProt accession

P47813

Gene

EIF1AX

Ensembl

ENSG00000173674

Chromosome

X

Canonical length

144 aa

Protein class

Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

144 residues, UniProt reviewed canonical sequence.

>P47813|EIF1AX
     1  MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM CFDGVKRLCH
    61  IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT
   121  FGPGDDDEIQ FDDIGDDDED IDDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF1AX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.44

Highest tissue expression

75 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EIF1AX.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 57 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Multiple myeloma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.39

gnomAD pLI

0.91

gnomAD missense Z

2.39

DepMap mean gene effect

-1.77

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ribosome assembly
• translational initiation

Molecular functions

• RNA binding
• translation factor activity, RNA binding
• translation initiation factor activity
• tRNA binding

Cellular components

• cytoplasm
• cytosol
• eukaryotic 43S preinitiation complex
• eukaryotic 48S preinitiation complex
• multi-eIF complex
• synapse

Protein domainsUniProt · Pfam · InterPro

• Translation initiation factor 1A (eIF-1A)
• RNA-binding domain, S1, IF1 type
• Nucleic acid-binding, OB-fold
• Translation initiation factor 1A (eIF-1A), conserved site
• Translation initiation factor 1A / IF-1

KeywordsUniProt

• Cytoplasm
• Host-virus interaction
• Initiation factor
• Protein biosynthesis
• RNA-binding
• tRNA-binding

InteractionsUniProt · HPA

Protein binding partners of EIF1AX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EIF5