EIF1

Protein identityUniProt · HPA

UniProt accession

P41567

Gene

EIF1

Ensembl

ENSG00000173812

Chromosome

17

Canonical length

113 aa

Protein class

Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Enables ribosomal small subunit binding activity and translation initiation factor activity. Involved in regulation of translational initiation and translational initiation. Located in cytoplasm and nucleus. Part of eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; and multi-eIF complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>P41567|EIF1
     1  MSAIQNLHSF DPFADASKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI ADDYDKKKLV
    61  KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLVEI GLAKDDQLKV HGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

1,182 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for EIF1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.51

gnomAD pLI

0.83

gnomAD missense Z

1.87

DepMap mean gene effect

-1.14

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of translational initiation
• translational initiation

Molecular functions

• ribosomal small subunit binding
• RNA binding
• translation factor activity, RNA binding
• translation initiation factor activity

Cellular components

• cytoplasm
• eukaryotic 43S preinitiation complex
• eukaryotic 48S preinitiation complex
• multi-eIF complex
• nucleus

Protein domainsUniProt · Pfam · InterPro

• SUI1 domain
• Eukaryotic translation initiation factor SUI1
• SUI1 domain superfamily
• Translation initiation factor SUI1

KeywordsUniProt

• Acetylation
• Cytoplasm
• Initiation factor
• Phosphoprotein
• Protein biosynthesis

InteractionsUniProt · HPA

Protein binding partners of EIF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EIF4G1
• EIF5
• RENT2
• UPF2