Seroatlas · Human Serome Atlas

EID2

EP300-interacting inhibitor of differentiation 2

Also known as: CRI2, EID-2, EID2_HUMAN, MGC20452

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6I1
Gene: EID2
Ensembl: ENSG00000176396
Chromosome: 19
Canonical length: 236 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables SMAD binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and transforming growth factor beta receptor complex assembly. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>Q8N6I1|EID2
     1  MSKLPADSSV PQTGAANGDR DVPQAEVGRG RREPAPAQPE EAGEGAMAAA RGGPVPAARE
    61  GRMAAARAAP AAAARGAPVA AAALARAAAA GRESPAAAAA REARMAEVAR LLGEPVDEEG
   121  PEGRPRSRHG NGGLAALPYL RLRHPLSVLG INYQQFLRHY LENYPIAPGR IQELEERRRR
   181  FVEACRAREA AFDAEYQRNP HRVDLDILTF TIALTASEVI NPLIEELGCD KFINRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EID2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 26 nTPM
hypothalamus: 22 nTPM
adrenal gland: 19 nTPM
basal ganglia: 19 nTPM
amygdala: 18 nTPM
hippocampal formation: 18 nTPM

Single-cell type

cytotrophoblasts: 58 nCPM
migrating cytotrophoblasts: 40 nCPM
fallopian tube ciliated cells: 27 nCPM
pancreatic islet cells: 25 nCPM
respiratory ciliated cells: 24 nCPM
müller glia: 24 nCPM

Immune cell

naive CD8 T-cell: 1.4 nTPM
memory CD4 T-cell: 1 nTPM
memory CD8 T-cell: 1 nTPM
naive CD4 T-cell: 1 nTPM
gdT-cell: 0.8 nTPM
MAIT T-cell: 0.8 nTPM

Brain region

cerebral cortex: 33 nTPM
hypothalamus: 26 nTPM
basal ganglia: 23 nTPM
pons: 22 nTPM
medulla oblongata: 21 nTPM
cerebellum: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0.3
gnomAD missense Z: 0.8
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

EP300-interacting inhibitor of differentiation

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EID2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EID2 as an antibody target. Whether an autoantibody or antibody against EID2 could matter depends on whether native EID2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EID2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EID2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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