Seroatlas · Human Serome Atlas

EFCAB7

EF-hand calcium-binding domain-containing protein 7

Also known as: EFCB7_HUMAN, KIAA1799, RP4-534K7.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8K855
Gene: EFCAB7
Ensembl: ENSG00000203965
Chromosome: 1
Canonical length: 629 aa
Protein class: Predicted intracellular proteins
Subcellular location: Primary cilium transition zone,Cytosol

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Predicted to be involved in positive regulation of protein import into nucleus; positive regulation of protein localization to ciliary membrane; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be part of plasma membrane protein complex. Predicted to be active in ciliary membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

629 residues, UniProt reviewed canonical sequence.

>A8K855|EFCAB7
     1  MAISPRSDAT FSSQKSTPSE SPRTKKFPLT EEEIFYMNCR AAYLTVFKSS LENIISKDQL
    61  YLALQHAGRN PSQKTINKYW TPQTAKLNFD DFCIILRKEK PTSKAELLKS FKQLDVNDDG
   121  CILHTDLYKF LTKRGEKMTR EEVNAIINLA DVNADGKFDY IKFCKLYMTT NEQCLKTTLE
   181  KLEVDSKLMR HQFGNHIEGS PERDPSPVPK PSPKITRKTD PETFLNKGDT RSSLLSATRK
   241  FKTSVSFTVT MGANGNRNSK LMEPNLIKDW QHMQSKGCFF LEEDGEIISH QYRMQIAQRS
   301  MVYLTIKPLN LSQVEGKPSP WLSVDTALYI LKENESQANL QLVCFTELRN REVFGWTGEL
   361  GPGIYWLIPS TTGCRLRKKI KPVTDEAQLV YRDETGELFL TKEFKSTLSD IFEVIDLDGN
   421  GLLSLEEYNF FELRTSGEKC DEDAWAVCRE NFDTKRNELT RQGFMDLNLM EANDREGDPC
   481  DLWVTLHSMG YNKALELTEA CPFVIDIYAE KCKPKIKAVH MEACSGQLEK AICKSVLSNG
   541  DAKVMDGYEN IIVHTYSCDT WITSVIENKS DEKVIIHISN ELSKNCINNR GLNIFAVEVG
   601  PKSTMVCQHV MPLNERQEWI YYCIYSLIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EFCAB7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

testis: 14 nTPM
parathyroid gland: 9.8 nTPM
retina: 8.3 nTPM
cerebellum: 7.9 nTPM
choroid plexus: 7.9 nTPM
ovary: 7.7 nTPM

Single-cell type

thymic myoid cells: 239 nCPM
late primary spermatocytes: 139 nCPM
choroid plexus epithelial cells: 92 nCPM
early primary spermatocytes: 82 nCPM
ependymal cells: 76 nCPM
cardiomyocytes: 70 nCPM

Immune cell

basophil: 10 nTPM
non-classical monocyte: 2.6 nTPM
naive B-cell: 1.9 nTPM
memory B-cell: 1.8 nTPM
MAIT T-cell: 1.6 nTPM
T-reg: 1.6 nTPM

Brain region

choroid plexus: 18 nTPM
hypothalamus: 16 nTPM
cerebellum: 15 nTPM
cerebral cortex: 14 nTPM
white matter: 13 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 1.03
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of protein import into nucleus
positive regulation of transcription by RNA polymerase II
protein localization to motile cilium
regulation of smoothened signaling pathway
positive regulation of protein localization to ciliary membrane

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EFCAB7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EFCAB7 as an antibody target. Whether an autoantibody or antibody against EFCAB7 could matter depends on whether native EFCAB7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EFCAB7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EFCAB7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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