Seroatlas · Human Serome Atlas

ECI1

Enoyl-CoA delta isomerase 1, mitochondrial

Also known as: DCI, ECI1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P42126
Gene
ECI1
Ensembl
ENSG00000167969
Chromosome
16
Canonical length
302 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Mitochondria
Quaternary structure
Homotrimer

OverviewNCBI Gene

This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

302 residues, UniProt reviewed canonical sequence.

>P42126|ECI1
     1  MALVASVRVP ARVLLRAGAR LPGAALGRTE RAAGGGDGAR RFGSQRVLVE PDAGAGVAVM
    61  KFKNPPVNSL SLEFLTELVI SLEKLENDKS FRGVILTSDR PGVFSAGLDL TEMCGRSPAH
   121  YAGYWKAVQE LWLRLYQSNL VLVSAINGAC PAGGCLVALT CDYRILADNP RYCIGLNETQ
   181  LGIIAPFWLK DTLENTIGHR AAERALQLGL LFPPAEALQV GIVDQVVPEE QVQSTALSAI
   241  AQWMAIPDHA RQLTKAMMRK ATASRLVTQR DADVQNFVSF ISKDSIQKSL QMYLERLKEE
   301  KG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ECI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
228 nTPM

Expression across tissuesHPA

Tissue

  • liver: 228 nTPM
  • skeletal muscle: 211 nTPM
  • heart muscle: 178 nTPM
  • kidney: 118 nTPM
  • thyroid gland: 101 nTPM
  • choroid plexus: 92 nTPM

Single-cell type

  • hepatocytes: 299 nCPM
  • cytotrophoblasts: 242 nCPM
  • salivary duct cells: 203 nCPM
  • respiratory ionocytes: 201 nCPM
  • epididymal efferent duct absorptive cells: 190 nCPM
  • thymic myoid cells: 177 nCPM

Immune cell

  • naive B-cell: 4.9 nTPM
  • memory B-cell: 4.4 nTPM
  • T-reg: 4 nTPM
  • intermediate monocyte: 3.8 nTPM
  • classical monocyte: 3.6 nTPM
  • NK-cell: 3.6 nTPM

Brain region

  • choroid plexus: 87 nTPM
  • thalamus: 47 nTPM
  • medulla oblongata: 40 nTPM
  • basal ganglia: 39 nTPM
  • cerebellum: 38 nTPM
  • hypothalamus: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.84
gnomAD pLI
0
gnomAD missense Z
-0.42
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ECI1 as an antibody target. Whether an autoantibody or antibody against ECI1 could matter depends on whether native ECI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ECI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ECI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ECI1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...