EBF4

Protein identityUniProt · HPA

UniProt accession

Q9BQW3

Gene

EBF4

Ensembl

ENSG00000088881

Chromosome

20

Canonical length

602 aa

Protein class

Predicted intracellular proteins, Transcription factors

Quaternary structure

Homodimer

OverviewNCBI Gene

EBF4 belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors, members of which play important roles in neural development and B-cell maturation (Wang et al., 2002 [PubMed 12139918]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

602 residues, UniProt reviewed canonical sequence.

>Q9BQW3|EBF4
     1  MFPAQDALPR SGLNLKEEPL LPAGLGSVRS WMQGAGILDA STAAQSGVGL ARAHFEKQPP
    61  SNLRKSNFFH FVLAMYDRQG QPVEVERTAF IDFVEKDREP GAEKTNNGIH YRLRLVYNNG
   121  LRTEQDLYVR LIDSMSKQAI IYEGQDKNPE MCRVLLTHEI MCSRCCDRKS CGNRNETPSD
   181  PVIIDRFFLK FFLKCNQNCL KNAGNPRDMR RFQVVVSTTV SVDGHVLAVS DNMFVHNNSK
   241  HGRRARRLDP SEAATPCIKA ISPGEGWTTG GATVIVIGDN FFDGLQVVFG NVLVWSELIT
   301  PHAIRVQTPP RHIPGVVEVT LSYKSKQFCK GCPGRFVYTA LNEPTIDYGF QRLQKVIPRH
   361  PGDPERLPKE VLLKRAADLA EALYGVPGSN QELLLKRAAD VAEALYSTPR APGPLAPLAP
   421  SHPHPAVVGI NAFSSPLAIA VGDATPGPEP GYARSCSSAS PRGFAPSPGS QQSGYGGGLG
   481  AGLGGYGAPG VAGLGVPGSP SFLNGSTATS PFAIMPSSPP LAAASSMSLP AAAPTTSVFS
   541  FSPVNMISAV KQRSAFAPVL RPPSSPPQAC PRAHGEGLPD QSFEDSDKFH SPARGLQGLA
   601  YS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EBF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

26 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EBF4.

Disease | ImmuneIEDB

Conditions an epitope on EBF4 was assayed in.

• ovarian cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.7

gnomAD pLI

0

gnomAD missense Z

1.81

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• positive regulation of transcription by RNA polymerase II
• regulation of transcription by RNA polymerase II
• T cell apoptotic process

Molecular functions

• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• DNA-binding transcription factor binding
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• zinc ion binding

Cellular components

• chromatin
• nucleus

Protein domainsUniProt · Pfam · InterPro

• IPT domain
• Transcription factor COE
• Immunoglobulin-like fold
• Immunoglobulin E-set
• Transcription factor COE, conserved site
• Transcription factor COE, DNA-binding domain
• Transcription factor COE, helix-loop-helix domain
• Transcription factor COE, IPT domain
• Transcription factor COE, DNA-binding domain superfamily
• IPT/TIG domain
• Transcription factor COE1 DNA-binding domain
• Transcription factor COE1 helix-loop-helix domain

KeywordsUniProt

• Activator
• Developmental protein
• DNA-binding
• Metal-binding
• Nucleus
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of EBF4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• STAT5A
• MAPK3