DYNAP
Dynactin-associated protein
Also known as: C18orf26, DYNAP_HUMAN, FLJ39106
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N1N2
- Gene
- DYNAP
- Ensembl
- ENSG00000178690
- Chromosome
- 18
- Canonical length
- 210 aa
- Protein class
- Predicted membrane proteins
OverviewNCBI Gene
Involved in several processes, including activation of protein kinase B activity; cellular response to ergosterol; and positive regulation of cell population proliferation. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
210 residues, UniProt reviewed canonical sequence.
>Q8N1N2|DYNAP
1 MVADIKGNEQ IEKYSWREAC DTGSSRMDRK HGKYILNVEH SENQPPITHP NDQEAHSSIC
61 WCLPSNDITS DVSPNLTGVC VNPGILAHSR CLQSESCNTQ VKEYCRNDWS MWKVFLACLL
121 ACVIMTAIGV LIICLVNNKG SANSSIVIQL STNDGECVTV KPGTPSPACP PTMTTTSTVP
181 ASTATESTTS TATAATTSTE PITVAPTDHLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DYNAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.67
- Highest tissue expression
- 28 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 28 nTPM
- retina: 2.4 nTPM
- spleen: 2.2 nTPM
- bone marrow: 2.1 nTPM
- epididymis: 1.9 nTPM
- tonsil: 1.8 nTPM
Single-cell type
- esophageal apical cells: 341 nCPM
- esophageal suprabasal cells: 101 nCPM
- suprabasal keratinocytes: 12 nCPM
- schwann cells: 2.1 nCPM
- esophageal basal cells: 1.4 nCPM
- ocular epithelial cells: 0.9 nCPM
Immune cell
- neutrophil: 0.8 nTPM
- non-classical monocyte: 0.8 nTPM
- eosinophil: 0.6 nTPM
- naive B-cell: 0.4 nTPM
- basophil: 0.3 nTPM
- classical monocyte: 0.3 nTPM
Brain region
- cerebral cortex: 21 nTPM
- cerebellum: 21 nTPM
- white matter: 21 nTPM
- hypothalamus: 20 nTPM
- basal ganglia: 20 nTPM
- thalamus: 20 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.73
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.6
- DepMap mean gene effect
- 0.14
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- activation of protein kinase B activity
- positive regulation of cell population proliferation
- regulation of apoptotic process
- cellular response to ergosterol
Cellular components
Protein domainsUniProt · Pfam · InterPro
- CLLAC-motif containing domain
- Dynactin-associated protein
- CLLAC-motif containing domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of DYNAP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DYNAP as an antibody target. Whether an autoantibody or antibody against DYNAP could matter depends on whether native DYNAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DYNAP is annotated at the cell surface, where native DYNAP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label DYNAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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