DYDC2
DPY30 domain-containing protein 2
Also known as: bA36D19.6, DYDC2_HUMAN, MGC16186
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96IM9
- Gene
- DYDC2
- Ensembl
- ENSG00000133665
- Chromosome
- 10
- Canonical length
- 177 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles,Cytosol,Principal piece
OverviewNCBI Gene
This gene encodes a member of a family of proteins that contains a DPY30 domain. This gene locus overlaps with a closely related gene on the opposite strand. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Canonical amino-acid sequenceUniProt
177 residues, UniProt reviewed canonical sequence.
>Q96IM9|DYDC2
1 METNYLKRCF GNCLAQALAE VAKVRPSDPI EYLAHWLYHY RKTAKAKEEN REKKIHLQEE
61 YDSSLKEMEM TEMLKQEEYQ IQQNCEKCHK ELTSETVSTK KTIFMQEDTN PLEKEALKQE
121 FLPGTSSLIP GMPQQVPPSE SAGQIDQNFK MPQEINYKEA FQHEVAHEMP PGSKSPFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DYDC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 92 nTPM
Expression across tissuesHPA
Tissue
- fallopian tube: 92 nTPM
- choroid plexus: 25 nTPM
- basal ganglia: 12 nTPM
- hippocampal formation: 12 nTPM
- testis: 10 nTPM
- hypothalamus: 9.6 nTPM
Single-cell type
- fallopian tube ciliated cells: 296 nCPM
- respiratory ciliated cells: 261 nCPM
- endometrial ciliated cells: 218 nCPM
- epididymal efferent duct ciliated cells: 184 nCPM
- ependymal cells: 83 nCPM
- late primary spermatocytes: 82 nCPM
Immune cell
- basophil: 0.7 nTPM
- plasmacytoid DC: 0.5 nTPM
- naive B-cell: 0.2 nTPM
- neutrophil: 0.2 nTPM
- NK-cell: 0.2 nTPM
- classical monocyte: 0.1 nTPM
Brain region
- midbrain: 14 nTPM
- medulla oblongata: 14 nTPM
- spinal cord: 14 nTPM
- choroid plexus: 12 nTPM
- white matter: 10 nTPM
- hypothalamus: 9.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.64
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.41
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
InteractionsUniProt · HPA
Protein binding partners of DYDC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DYDC2 as an antibody target. Whether an autoantibody or antibody against DYDC2 could matter depends on whether native DYDC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DYDC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DYDC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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