Seroatlas · Human Serome Atlas

DRC7

Dynein regulatory complex subunit 7

Also known as: C16orf50, CCDC135, CFAP50, DKFZp434I099, DRC7_HUMAN, FAP50

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IY82
Gene: DRC7
Ensembl: ENSG00000159625
Chromosome: 16
Canonical length: 874 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in sperm axoneme assembly. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

874 residues, UniProt reviewed canonical sequence.

>Q8IY82|DRC7
     1  MEVLREKVEE EEEAEREEAA EWAEWARMEK MMRPVEVRKE EITLKQETLR DLEKKLSEIQ
    61  ITVSAELPAF TKDTIDISKL PISYKTNTPK EEHLLQVADN FSRQYSHLCP DRVPLFLHPL
   121  NECEVPKFVS TTLRPTLMPY PELYNWDSCA QFVSDFLTMV PLPDPLKPPS HLYSSTTVLK
   181  YQKGNCFDFS TLLCSMLIGS GYDAYCVNGY GSLDLCHMDL TREVCPLTVK PKETIKKEEK
   241  VLPKKYTIKP PRDLCSRFEQ EQEVKKQQEI RAQEKKRLRE EEERLMEAEK AKPDALHGLR
   301  VHSWVLVLSG KREVPENFFI DPFTGHSYST QDEHFLGIES LWNHKNYWIN MQDCWNCCKD
   361  LIFDLGDPVR WEYMLLGTDK SQLSLTEEDD SGINDEDDVE NLGKEDEDKS FDMPHSWVEQ
   421  IEISPEAFET RCPNGKKVIQ YKRAKLEKWA PYLNSNGLVS RLTTYEDLQC TNILEIKEWY
   481  QNREDMLELK HINKTTDLKT DYFKPGHPQA LRVHSYKSMQ PEMDRVIEFY ETARVDGLMK
   541  REETPRTMTE YYQGRPDFLS YRHASFGPRV KKLTLSSAES NPRPIVKITE RFFRNPAKPA
   601  EEDVAERVFL VAEERIQLRY HCREDHITAS KREFLRRTEV DSKGNKIIMT PDMCISFEVE
   661  PMEHTKKLLY QYEAMMHLKR EEKLSRHQVW ESELEVLEIL KLREEEEAAH TLTISIYDTK
   721  RNEKSKEYRE AMERMMHEEH LRQVETQLDY LAPFLAQLPP GEKLTCWQAV RLKDECLSDF
   781  KQRLINKANL IQARFEKETQ ELQKKQQWYQ ENQVTLTPED EDLYLSYCSQ AMFRIRILEQ
   841  RLNRHKELAP LKYLALEEKL YKDPRLGELQ KIFA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DRC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

testis: 43 nTPM
fallopian tube: 20 nTPM
choroid plexus: 12 nTPM
basal ganglia: 2.2 nTPM
hypothalamus: 2 nTPM
hippocampal formation: 1.9 nTPM

Single-cell type

late spermatids: 207 nCPM
late primary spermatocytes: 179 nCPM
respiratory ciliated cells: 138 nCPM
early spermatids: 111 nCPM
ependymal cells: 105 nCPM
fallopian tube ciliated cells: 74 nCPM

Immune cell

basophil: 11 nTPM
neutrophil: 1.3 nTPM
eosinophil: 0.7 nTPM
classical monocyte: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
total PBMC: 0.1 nTPM

Brain region

choroid plexus: 24 nTPM
midbrain: 20 nTPM
medulla oblongata: 14 nTPM
spinal cord: 9.1 nTPM
pons: 7.1 nTPM
thalamus: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Papain-like cysteine peptidase superfamily
CEP76/DRC7, peptidase-like domain
CEP76 peptidase-like domain
Dynein regulatory complex subunit 7
Dynein regulatory complex subunit 7, MORN domain
Dynein regulatory complex subunit 7, C-terminal
Dynein regulatory complex subunit 7 MORN domain
Dynein regulatory complex subunit 7 C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DRC7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DRC3
DRC4
DRC5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DRC7 as an antibody target. Whether an autoantibody or antibody against DRC7 could matter depends on whether native DRC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DRC7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DRC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...