Seroatlas · Human Serome Atlas

DRC3

Dynein regulatory complex subunit 3

Also known as: CFAP134, DKFZP586M1120, DRC3_HUMAN, LRRC48

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H069
Gene: DRC3
Ensembl: ENSG00000171962
Chromosome: 17
Canonical length: 523 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mid piece,Principal piece,End piece

OverviewNCBI Gene

Located in axoneme. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>Q9H069|DRC3
     1  MNQPCNSMEP RVMDDDMLKL AVGDQGPQEE AGQLAKQEGI LFKDVLSLQL DFRNILRIDN
    61  LWQFENLRKL QLDNNIIEKI EGLENLAHLV WLDLSFNNIE TIEGLDTLVN LEDLSLFNNR
   121  ISKIDSLDAL VKLQVLSLGN NRIDNMMNII YLRRFKCLRT LSLSRNPISE AEDYKMFICA
   181  YLPDLMYLDY RRIDDHTKKL AEAKHQYSID ELKHQENLMQ AQLEDEQAQR EELEKHKTAF
   241  VEHLNGSFLF DSMYAEDSEG NNLSYLPGVG ELLETYKDKF VIICVNIFEY GLKQQEKRKT
   301  ELDTFSECVR EAIQENQEQG KRKIAKFEEK HLSSLSAIRE ELELPNIEKM ILECSADISE
   361  LFDALMTLEM QLVEQLEETI NMFERNIVDM VGLFIENVQS LMAQCRDLEN HHHEKLLEIS
   421  ISTLEKIVEG DLDEDLPNDL RALFVDKDTI VNAVGASHDI HLLKIDNRED ELVTRINSWC
   481  TRLIDRIHKD EIMRNRKRVK EINQYIDHMQ SELDNLECGD ILD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DRC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 58 nTPM
choroid plexus: 25 nTPM
epididymis: 11 nTPM
testis: 11 nTPM
pituitary gland: 8.7 nTPM
retina: 8.2 nTPM

Single-cell type

respiratory ciliated cells: 459 nCPM
fallopian tube ciliated cells: 354 nCPM
ependymal cells: 311 nCPM
epididymal efferent duct ciliated cells: 239 nCPM
endometrial ciliated cells: 206 nCPM
cone photoreceptor cells: 85 nCPM

Immune cell

neutrophil: 0.6 nTPM
eosinophil: 0.5 nTPM
memory CD8 T-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
myeloid DC: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM

Brain region

choroid plexus: 39 nTPM
midbrain: 24 nTPM
medulla oblongata: 20 nTPM
spinal cord: 15 nTPM
pons: 9.3 nTPM
hypothalamus: 8.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DRC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DRC1
DRC5
DRC7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DRC3 as an antibody target. Whether an autoantibody or antibody against DRC3 could matter depends on whether native DRC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DRC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DRC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...